Technology Process of Glycine,
N-[N-[N-[N-[1-[1-[N-[1-[N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-L-tyrosyl]
-L-prolyl]-L-phenylalanyl]-L-prolyl]-L-prolyl]glycyl]-L-isoleucyl]glycyl]-,
phenylmethyl ester
There total 19 articles about Glycine,
N-[N-[N-[N-[1-[1-[N-[1-[N-[N-[(phenylmethoxy)carbonyl]-L-valyl]-L-tyrosyl]
-L-prolyl]-L-phenylalanyl]-L-prolyl]-L-prolyl]glycyl]-L-isoleucyl]glycyl]-,
phenylmethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 94 percent / H2, 0.3 M hydrogen chloride / Pd black / methanol
2: NMM, HOBt, DCC / THF, 0 deg C, overnight
3: 70 percent / 2 m NaOH / methanol
4: DCC, NMM, HOBt / THF, 0 deg C, overnight
5: 80 percent / 2 M sodium hydroxide / methanol / 2 h / Ambient temperature
6: HOBt, NMM, DCC
With
4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
palladium;
In
methanol;
DOI:10.1246/bcsj.57.97
- Guidance literature:
-
Multi-step reaction with 7 steps
1: NMM, DCC / acetonitrile, 0 deg C, overnight
2: 60 percent / H2 / Pd black / methanol
3: 1) NMM, ECF, 2) NMM
4: 98 percent / 4 M hydrogen chloride / dioxane / 1 h / Ambient temperature
5: DCC, NMM, HOBt / THF, 0 deg C, overnight
6: 80 percent / 2 M sodium hydroxide / methanol / 2 h / Ambient temperature
7: HOBt, NMM, DCC
With
4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; chloroformic acid ethyl ester; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
palladium;
In
1,4-dioxane; methanol;
DOI:10.1246/bcsj.57.97
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 60 percent / H2 / Pd black / methanol
2: 1) NMM, ECF, 2) NMM
3: 98 percent / 4 M hydrogen chloride / dioxane / 1 h / Ambient temperature
4: DCC, NMM, HOBt / THF, 0 deg C, overnight
5: 80 percent / 2 M sodium hydroxide / methanol / 2 h / Ambient temperature
6: HOBt, NMM, DCC
With
4-methyl-morpholine; hydrogenchloride; sodium hydroxide; hydrogen; chloroformic acid ethyl ester; benzotriazol-1-ol; dicyclohexyl-carbodiimide;
palladium;
In
1,4-dioxane; methanol;
DOI:10.1246/bcsj.57.97