Tetrahydro-2-furyl acetate

Base Information

• Chemical Name: Tetrahydro-2-furyl acetate
• CAS No.: 1608-67-9
• Molecular Formula: C6H10O3
• Molecular Weight: 130.144
• Hs Code.: 2932190090
• European Community (EC) Number: 216-536-5
• DSSTox Substance ID: DTXSID80936398
• Nikkaji Number: J27.268J
• Mol file: 1608-67-9.mol

Synonyms:oxolan-2-yl acetate;1608-67-9;tetrahydrofuran-2-yl acetate;Tetrahydro-2-furyl acetate;2-ACETOXYTETRAHYDROFURAN;2-Furanol, tetrahydro-, 2-acetate;EINECS 216-536-5;tetrahydrofuran-2-ylacetate;SCHEMBL2739848;2-Furanol,tetrahydro-,2-acetate;DTXSID80936398;BAA60867;AKOS006310845;AS-78295;CS-0160246;D94546

Chemical Property of Tetrahydro-2-furyl acetate

Chemical Property:

• Vapor Pressure: 1.92mmHg at 25°C
• Refractive Index: 1.437
• Boiling Point: 164.9 °C at 760 mmHg
• Flash Point: 58.1 °C
• PSA: 35.53000
• Density: 1.08 g/cm³
• LogP: 0.68600
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 130.062994177
• Heavy Atom Count: 9
• Complexity: 111

Purity/Quality:

95% ^*data from raw suppliers

2-ACETOXYTETRAHYDROFURAN 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)OC1CCCO1

Technology Process of Tetrahydro-2-furyl acetate

There total 4 articles about Tetrahydro-2-furyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Butane-1,4-diol (110-63-4) + Dess-Martin periodane (87413-09-0) → 2-acetoxytetrahydrofuran (1608-67-9)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.583333h;

DOI:10.1055/s-2001-14610

Reference yield: 77.0%

2,3-dihydro-2H-furan (1191-99-7,75454-45-4) + acetic acid (64-19-7,77671-22-8) → 2-acetoxytetrahydrofuran (1608-67-9)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; at 0 - 20 ℃; for 1h; Inert atmosphere;

DOI:10.1021/jacs.6b11993

Reference yield: 14.0%

tetrahydrofuran (109-99-9,24979-97-3,77392-70-2) + methyl(phenylsulfonyl)amide (5183-78-8) → 2-acetoxytetrahydrofuran (1608-67-9) + C12H17NO3S

Guidance literature:

With [bis(acetoxy)iodo]benzene; at 60 ℃; for 16h;

DOI:10.1039/c4ra09665g

upstream raw materials:

2,3-dihydro-2H-furan

acetic acid

Butane-1,4-diol

Dess-Martin periodane

Downstream raw materials:

1-(tetrahydro-furan-2-yl)-uracil

Refernces

• 1、 Lee, Sunggi,Kaib, Philip S. J.,List, Benjamin. "Asymmetric Catalysis via Cyclic, Aliphatic Oxocarbenium Ions". supporting information. p. 2156 - 2159. Retrieved 2017/02/23.
• 2、 Dolman, Nigel P.,More, Julia C. A.,Alt, Andrew,Knauss, Jody L.,Troop, Helen M.,Bleakman, David,Collingridge, Graham L.,Jane, David E.. "Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists". . p. 2579 - 2592. Retrieved 2007/10/03.