Butanal, 3-methyl-4-(phenylmethoxy)-, (3R)-

Base Information

• Chemical Name: Butanal, 3-methyl-4-(phenylmethoxy)-, (3R)-
• CAS No.: 90865-70-6
• Molecular Formula: C12H16O2
• Molecular Weight: 192.258
• Mol file: 90865-70-6.mol

Synonyms:

Chemical Property of Butanal, 3-methyl-4-(phenylmethoxy)-, (3R)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Butanal, 3-methyl-4-(phenylmethoxy)-, (3R)-

There total 40 articles about Butanal, 3-methyl-4-(phenylmethoxy)-, (3R)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

(3R)-4-benzyloxy-3-methyl-butanonitrile (104265-24-9) → [3R]-4-Benzyloxy-3-methylbutanal (90865-70-6)

Guidance literature:

With diisobutylaluminium hydride; In dichloromethane; at 0 ℃;

DOI:10.1016/S0040-4039(00)00158-1

Reference yield: 89.0%

(R)-1-((2-methylpent-4-enyloxy)methyl)benzene (126788-88-3) → [3R]-4-Benzyloxy-3-methylbutanal (90865-70-6)

Guidance literature:

With osmium(VIII) oxide; potassium metaperiodate; In water; acetone; for 6h; Ambient temperature;

DOI:10.1021/ja00164a023

Reference yield: 86.0%

(E)-4-(Benzyloxy)-N,N-diethyl-3-methylbut-2-enylamine (90809-13-5) → [3R]-4-Benzyloxy-3-methylbutanal (90865-70-6)

Guidance literature:

ClO4; In tetrahydrofuran; at 65 ℃; for 137h; yields after hydrolysis (50percent AcOH/H₂O);

DOI:10.1002/hlca.19900730516

upstream raw materials:

(R)-3-(benzyloxy)-2-methylpropan-1-ol

(R)-1-((2-methylpent-4-enyloxy)methyl)benzene

(R)-5-Benzyloxy-1-hydroxy-4-methyl-pentan-2-one

(E)-4-(Benzyloxy)-N,N-diethyl-3-methylbut-2-enylamine

Downstream raw materials:

(4S,6R)-7-(benzyloxy)-6-methylhept-1-en-4-ol

(2S,4R)-2-amino-5-(benzyloxy)-4-methylpentanenitrile

(S_S,2S,4R)-(+)-N-(p-toluenesulfinyl)-2-amino-5-(benzyloxy)-4-methylpentanenitrile

C₂₄H₂₄O₃

Refernces

• 1、 Zhang, Hong-Li,Sun, Zhi-Feng,Zhou, Lu-Nan,Liu, Lu,Zhang, Tao,Du, Zhen-Ting. "Synthesis of the sex pheromone of the tea tussock moth based on a resource chemistry strategy". . . Retrieved 2018/06/15.
• 2、 Chorley, Daniel F.,Chen, Jack Li-Yang,Furkert, Daniel P.,Sperry, Jonathan,Brimble, Margaret A.. "Total synthesis of danshenspiroketallactone". scheme or table. p. 128 - 130. Retrieved 2012/02/03.