2,5-Dibromothiazole

Base Information

• Chemical Name: 2,5-Dibromothiazole
• CAS No.: 4175-78-4
• Molecular Formula: C3HBr2NS
• Molecular Weight: 242.922
• Hs Code.: 29341000
• Mol file: 4175-78-4.mol

Synonyms:2,5-Dibromothiazole;NSC 222407;

Chemical Property of 2,5-Dibromothiazole

Chemical Property:

• Appearance/Colour: White to brown crystalline powder
• Vapor Pressure: 0.0518mmHg at 25°C
• Melting Point: 45-49 °C(lit.)
• Refractive Index: 1.649
• Boiling Point: 242.8 °C at 760 mmHg
• PKA: -0.88±0.10(Predicted)
• Flash Point: 100.6 °C
• PSA: 41.13000
• Density: 2.324 g/cm³
• LogP: 2.66810
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• Solubility.: soluble in Methanol

Purity/Quality:

99% ^*data from raw suppliers

2,5-Dibromothiazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

Useful:

• Uses: Used as a building block in material science.1,2 2,5-Dibromothiazole is used in the preparation of arylthiazolylpiperidine derivatives and analogs for use as survival motor neuron (SMN) protein production modulators. Used as a building block in material science.

Technology Process of 2,5-Dibromothiazole

There total 1 articles about 2,5-Dibromothiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,3-thiazole (288-47-1) → 2-bromo-1,3-thiazole (3034-53-5,215777-74-5) + 2,5-dibromo-1,3-thiazole (4175-78-4)

Guidance literature:

With aluminium trichloride; bromine; at 100 - 150 ℃; for 2.5h; Product distribution; Mechanism; Diff_. time, diff. temp.,presence of solvent, N-Bromosuccinimide;

DOI:10.1007/BF00575251

Reference yield: 100.0%

2,5-dibromo-1,3-thiazole (4175-78-4) + 2-chloro-4-methoxyphenol (18113-03-6) → 5-bromo-2-(2-chloro-4-methoxy-phenoxy)-thiazole (936247-38-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 105 ℃; for 3h;

Reference yield: 99.0%

2,5-dibromo-1,3-thiazole (4175-78-4) + 4-isopropoxyphenol (7495-77-4) → 5-bromo-2-(4-isopropoxy-phenoxy)-thiazole (903886-65-7)

Guidance literature:

With potassium carbonate; In dimethyl sulfoxide; at 95 ℃;

upstream raw materials:

1,3-thiazole

Downstream raw materials:

2,5-bis-(2,4,6-trinitro-phenyl)-thiazole

5-bromo-2-(4-chloro-phenylsulfanyl)-thiazole

5-bromo-2-(2,4,5-trichloro-phenylsulfanyl)-thiazole

5-Bromthiazolin-2-thion

Refernces