4'-AMINO-BIPHENYL-4-CARBOXYLIC ACID

Base Information

• Chemical Name: 4'-AMINO-BIPHENYL-4-CARBOXYLIC ACID
• CAS No.: 5730-78-9
• Molecular Formula: C13H11NO2
• Molecular Weight: 213.236
• Hs Code.: 2922499990
• Mol file: 5730-78-9.mol

Synonyms:4-Biphenylcarboxylicacid, 4'-amino- (6CI,7CI,8CI);4-(p-Aminophenyl)benzoic acid;4'-Amino-4-biphenylcarboxylic acid;NSC 210547;p-(p-Aminophenyl)benzoic acid;

Chemical Property of 4'-AMINO-BIPHENYL-4-CARBOXYLIC ACID

Chemical Property:

• Melting Point: 227-236℃
• Boiling Point: 421.1 °C at 760 mmHg
• PKA: 4.42±0.10(Predicted)
• Flash Point: 208.5 °C
• PSA: 63.32000
• Density: 1.257g/cm³
• LogP: 3.21520
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

99%, ^*data from raw suppliers

4-Aminobiphenyl-4''-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Aminobiphenyl-4''-carboxylic Acid, is an building block that can be used for the synthesis of Biphenyl and biphenyl ether compounds, that block DNA binding of the Human Papillomavirus (HPVs) E2 Protein, and thus can be used for the development of antiviral agents that interfere with HPV replication.

Technology Process of 4'-AMINO-BIPHENYL-4-CARBOXYLIC ACID

There total 14 articles about 4'-AMINO-BIPHENYL-4-CARBOXYLIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

4'-nitro-biphenyl-4-carboxylic acid (92-89-7) → 4-(4-aminophenyl)benzoic acid (5730-78-9)

Guidance literature:

With sodium hydroxide; hydrogen; platinum(IV) oxide; In methanol; water;

DOI:10.1016/S0960-894X(98)00433-8

Reference yield: 59.0%

4'-amino-(1,1'-biphenyl)-4-carboxylic acid hydrochloride (41567-82-2) → 4-(4-aminophenyl)benzoic acid (5730-78-9)

Guidance literature:

With triethylamine; In ethanol; at 80 ℃; for 1h;

DOI:10.1002/ardp.201000091

Reference yield: 21.0%

2-(4'-nitrobiphenyl-4-yl)-5-phenyl-1,3,4-oxadiazole (136180-43-3) → 4-(4-aminophenyl)benzoic acid (5730-78-9)

Guidance literature:

With phosphorus; hydrogen iodide; In acetic acid; for 15h; Heating;

upstream raw materials:

4-amino-4'-cyanobiphenyl

4'-nitro-biphenyl-4-carboxylic acid

2-(4'-nitrobiphenyl-4-yl)-5-phenyl-1,3,4-oxadiazole

methyl 4’-amino-[1,1’-biphenyl]-4-carboxylate

Downstream raw materials:

4'-[6-(4-Chloro-benzyloxycarbonylamino)-hexanoylamino]-biphenyl-4-carboxylic acid

C₂₇H₃₀ClN₃O₄S

C₂₂H₁₅FN₄O₄

C₂₆H₂₆N₂O₄

Refernces

• 1、 Chen, Jinshui,Song, Yun,Bojadzic, Damir,Tamayo-Garcia, Alejandro,Landin, Ana Marie,Blomberg, Bonnie B.,Buchwald, Peter. "Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction". supporting information. p. 8906 - 8922. Retrieved 2017/11/14.
• 2、 -. "PIPERAZINE AND HOMOPIPERAZINE COMPOUNDS". . . Retrieved 2008/06/13.