2,8-DIMETHYL-4-HYDROXYQUINOLINE

Base Information

• Chemical Name: 2,8-DIMETHYL-4-HYDROXYQUINOLINE
• CAS No.: 15644-80-1
• Molecular Formula: C11H11NO
• Molecular Weight: 173.214
• Hs Code.: 2933499090
• Mol file: 15644-80-1.mol

Synonyms:2,8-Dimethyl-4-hydroxyquinoline;2,8-Dimethyl-4-quinolinol;4-Hydroxy-2,8-dimethylquinoline;NSC 31466;

Chemical Property of 2,8-DIMETHYL-4-HYDROXYQUINOLINE

Chemical Property:

• Vapor Pressure: 0.00184mmHg at 25°C
• Melting Point: 262.3°C
• Refractive Index: 1.566
• Boiling Point: 292.4 °C at 760 mmHg
• Flash Point: 124.9 °C
• PSA: 33.12000
• Density: 1.107g/cm³
• LogP: 2.55720
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

2,8-Dimethylquinolin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,8-DIMETHYL-4-HYDROXYQUINOLINE

There total 9 articles about 2,8-DIMETHYL-4-HYDROXYQUINOLINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 3-[(2-methylphenyl)amino]but-2-enoate (33240-19-6) → 2,8-dimethyl-quinolin-4-ol (15644-80-1)

Guidance literature:

In diphenylether; at 250 ℃; for 1h;

Reference yield:

2-ethylbutyl 3-oxobutanoate (13562-88-4) + o-toluidine (95-53-4) → 2,8-dimethyl-quinolin-4-ol (15644-80-1)

Guidance literature:

With calcium sulfate; at 95 - 100 ℃; Erhitzen des Reaktionsprodukts in Biphenyl und Diphenylaether auf 250grad-260grad;

DOI:10.1021/ja01187a025

Reference yield:

acetoacetic acid methyl ester (105-45-3) + o-toluidine (95-53-4) → 2,8-dimethyl-quinolin-4-ol (15644-80-1)

Guidance literature:

upstream raw materials:

ethyl (Z)-3-(o-tolylamino)but-2-enoate

ethyl acetoacetate

o-toluidine

2-ethylbutyl 3-oxobutanoate

Downstream raw materials:

4-chloro-2,8-dimethylquinoline

4-hydrazino-2,8-dimethylquinoline

2-methyl-6-(3-methyl-1H-pyrazol-5-yl)aniline

2,8-dimethyl-3-formyl-4-hydroxyquinoline

Refernces

• 1、 -. "HETEROCYCLIC CGRP RECEPTOR ANTAGONISTS". Page/Page column 54. . Retrieved 2016/05/19.
• 2、 Nandhakumar,Suresh,Jude, A.L. Calistus,Rajesh kannan,Mohan. "Synthesis, antimicrobial activities and cytogenetic studies of newer diazepino quinoline derivatives via Vilsmeier-Haack reaction". . p. 1128 - 1136. Retrieved 2008/03/12.