4-bromophenyl 2-thiophenecarboxylate

Base Information

• Chemical Name: 4-bromophenyl 2-thiophenecarboxylate
• CAS No.: 91635-19-7
• Molecular Formula: C11H7BrO2S
• Molecular Weight: 283.145
• Mol file: 91635-19-7.mol

Synonyms:Thiophene-2-carboxylic acid 4-bromo-phenyl ester;Thiophen-2-carbonsaeure-<4-bromphenylester>;thiophene-2-carboxylic acid-(4-bromo-phenyl ester);Thiophen-2-carbonsaeure-(4-brom-phenylester);

Chemical Property of 4-bromophenyl 2-thiophenecarboxylate

Chemical Property:

• PSA: 54.54000
• LogP: 3.72980

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-bromophenyl 2-thiophenecarboxylate

There total 3 articles about 4-bromophenyl 2-thiophenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2-Thiophenecarbonyl chloride (5271-67-0) + 4-bromo-phenol (106-41-2) → 4-bromophenyl-2-thiophenecarboxylate (91635-19-7)

Guidance literature:

With magnesium; In benzene; for 1h; Heating;

Reference yield: 66.0%

2-thiophenylcarboxylic acid (527-72-0) + 4-bromo-phenol (106-41-2) → 4-bromophenyl-2-thiophenecarboxylate (91635-19-7)

Guidance literature:

With pyridine; trichlorophosphate;

Reference yield:

copper(I) thiophene-2-carboxylate (1292766-17-6) + 4-Bromobenzoic acid (586-76-5) → 4-bromophenyl-2-thiophenecarboxylate (91635-19-7)

Guidance literature:

4-Bromobenzoic acid; With lithium hydroxide; In water; acetonitrile; at 25 ℃; for 1h;

copper(I) thiophene-2-carboxylate; With copper(II) bis(trifluoromethanesulfonate); In acetonitrile; at 35 ℃; for 15h; Irradiation; Inert atmosphere; Glovebox;

DOI:10.1002/anie.202108971

upstream raw materials:

2-Thiophenecarbonyl chloride

4-bromo-phenol

2-thiophenylcarboxylic acid

copper(I) thiophene-2-carboxylate

Downstream raw materials:

4-bromo-phenol

5-bromo-2-hydroxyphenyl-2-thienylmethanone

C₁₃H₁₀BrNO₃S

(5-Bromo-2-hydroxy-phenyl)-thiophen-2-yl-methanone oxime

Refernces

• 1、 Lee, Chang Kiu,Yu, Ji Sook,Lee, Hye-Jin. "Determination of aromaticity indices of thiophene and furan by nuclear magnetic resonance spectroscopic analysis of their phenyl esters". . p. 1207 - 1217. Retrieved 2007/10/03.
• 2、 Thakar,Padhye. "Synthesis and antifungal activity of 3-furyl and 3-thienyl-substituted-1,2-benzisoxazoles". . p. 715 - 716. Retrieved 2007/10/02.