TERT-BUTYL 4-(3-(ETHOXYCARBONYL)-2-OXOPROPYL)PIPERIDINE-1-CARBOXYLATE

Base Information

• Chemical Name: TERT-BUTYL 4-(3-(ETHOXYCARBONYL)-2-OXOPROPYL)PIPERIDINE-1-CARBOXYLATE
• CAS No.: 916791-39-4
• Molecular Formula: C₁₆H₂₇NO₅
• Molecular Weight: 313.394
• Hs Code.: 2933399090
• Mol file: 916791-39-4.mol

Synonyms:1-Boc-b-oxo-4-piperidinebutanoic acid ethyl ester;

Chemical Property of TERT-BUTYL 4-(3-(ETHOXYCARBONYL)-2-OXOPROPYL)PIPERIDINE-1-CARBOXYLATE

Chemical Property:

• PSA: 72.91000
• LogP: 2.48380

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 3-oxo-4-(1-Boc-4-piperidyl)butyrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of TERT-BUTYL 4-(3-(ETHOXYCARBONYL)-2-OXOPROPYL)PIPERIDINE-1-CARBOXYLATE

There total 1 articles about TERT-BUTYL 4-(3-(ETHOXYCARBONYL)-2-OXOPROPYL)PIPERIDINE-1-CARBOXYLATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl potassium malonate (6148-64-7) + 2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid (157688-46-5) → 4-(3-ethoxycarbonyl-2-oxopropyl)piperidine-1-carboxylic acid tert-butyl ester (916791-39-4)

Guidance literature:

2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid; With 1,1'-carbonyldiimidazole; In tetrahydrofuran; at 20 ℃; for 5h;

ethyl potassium malonate; With magnesium chloride; In tetrahydrofuran; at 20 ℃; for 23h; Heating / reflux;

With hydrogenchloride; In tetrahydrofuran; water; at 0 ℃; pH=7;

upstream raw materials:

ethyl potassium malonate

2-(1-(tert-butoxycarbonyl)piperidin-4-yl)acetic acid

Refernces