1-(6-Chloro-pyridazino-3-yl)piperidine

Base Information

• Chemical Name: 1-(6-Chloro-pyridazino-3-yl)piperidine
• CAS No.: 1722-11-8
• Molecular Formula: C9H12ClN3
• Molecular Weight: 197.667
• Hs Code.: 2933990090
• Mol file: 1722-11-8.mol

Synonyms:Pyridazine,3-chloro-6-piperidino- (7CI,8CI);3-Chloro-6-(piperidin-1-yl)pyridazine;3-Chloro-6-piperidinopyridazine;1-(6-Chloro-pyridazino-3-yl)piperidine;

Chemical Property of 1-(6-Chloro-pyridazino-3-yl)piperidine

Chemical Property:

• Vapor Pressure: 3.02E-06mmHg at 25°C
• Melting Point: 80～82℃
• Refractive Index: 1.564
• Boiling Point: 388.6 °C at 760 mmHg
• PKA: 3.62±0.10(Predicted)
• Flash Point: 188.8 °C
• PSA: 29.02000
• Density: 1.234 g/cm³
• LogP: 2.18530
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

3-Chloro-6-(piperidin-1-yl)pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(6-Chloro-pyridazino-3-yl)piperidine

There total 1 articles about 1-(6-Chloro-pyridazino-3-yl)piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

piperidine (110-89-4) + 3,6-dichlorpyridazine (141-30-0) → 3-chloro-6-(piperidin-1-yl)pyridazine (1722-11-8)

Guidance literature:

With triethylamine; In ethanol; for 3h; Reflux;

DOI:10.1016/j.tet.2015.05.056

Reference yield: 68.0%

3-chloro-6-(piperidin-1-yl)pyridazine (1722-11-8) + phenylboronic acid (98-80-6) → 3-phenyl-6-(piperidin-1-yl)pyridazine (68206-18-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In water; acetonitrile; at 20 ℃; for 18h; Inert atmosphere; Reflux;

DOI:10.1016/j.ejmech.2015.03.025

Reference yield: 42.0%

3-chloro-6-(piperidin-1-yl)pyridazine (1722-11-8) + phenylacetylene (536-74-3) → 3-phenylethynyl-6-piperidinopyridazine (77778-14-4)

Guidance literature:

With diethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; at 70 ℃; for 24h;

DOI:10.1248/cpb.28.3488

upstream raw materials:

piperidine

3,6-dichlorpyridazine

Downstream raw materials:

3-phenylethynyl-6-piperidinopyridazine

1-{3-[7-(6-piperidin-1-yl-pyridazin-3-yl)-imidazo[1,2-a]pyridin-3-yl]phenyl}-3-(2,2,2-trifluoroethyl)urea

3-phenyl-6-(piperidin-1-yl)pyridazine

Refernces

• 1、 Sengmany, Stéphane,Lebre, Julie,Le Gall, Ewan,Léonel, Eric. "Selective mono-amination of dichlorodiazines". . p. 4859 - 4867. Retrieved 2015/08/03.
• 2、 Sengmany, Stephane,Vitu-Thiebaud, Arnaud,Le Gall, Erwan,Condon, Sylvie,Leonel, Eric,Thobie-Gautier, Christine,Pipelier, Muriel,Lebreton, Jacques,Dubreuil, Didier. "An electrochemical nickel-catalyzed arylation of 3-amino-6- chloropyridazines". . p. 370 - 379. Retrieved 2013/03/13.