Technology Process of 1-Piperidinecarboxylic acid,
4-[4-[1-[(dimethylamino)sulfonyl]-3-methyl-1H-pyrazol-4-yl]phenyl]-4-[(3-
methoxyphenoxy)methyl]-, 1,1-dimethylethyl ester
There total 9 articles about 1-Piperidinecarboxylic acid,
4-[4-[1-[(dimethylamino)sulfonyl]-3-methyl-1H-pyrazol-4-yl]phenyl]-4-[(3-
methoxyphenoxy)methyl]-, 1,1-dimethylethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
3-methyl-1-sulphonic acid dimethylamide-pyrazole-4-boronic acid; 4-(4-bromo-phenyl)-4-(3-methoxy-phenoxymethyl)-piperidine-1-carboxylic acid tert-butyl ester;
With
potassium phosphate;
tetrakis(triphenylphosphine) palladium(0);
In
methanol; ethanol; water; toluene;
at 90 ℃;
In
methanol; ethanol; water; toluene;
at 20 - 90 ℃;
for 3h;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: triethylamine / N,N-dimethyl-formamide / 3.5 h / 20 °C
2.1: caesium carbonate / N,N-dimethyl-formamide / 28 h / 50 - 100 °C
3.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / methanol; ethanol; water; toluene / 90 °C
3.2: bis(tri-tert-butyl)phosphine / 3 h / 20 - 90 °C
With
potassium phosphate; caesium carbonate; triethylamine;
tetrakis(triphenylphosphine) palladium(0);
In
methanol; ethanol; water; N,N-dimethyl-formamide; toluene;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: pyridine; carbon tetrabromide; triphenylphosphine / 1.5 h / 60 °C
2.1: morpholine; 1,8-diazabicyclo[5.4.0]undec-7-ene / dichloromethane / 2 h
3.1: triethylamine / N,N-dimethyl-formamide / 3.5 h / 20 °C
4.1: caesium carbonate / N,N-dimethyl-formamide / 28 h / 50 - 100 °C
5.1: potassium phosphate / tetrakis(triphenylphosphine) palladium(0) / methanol; ethanol; water; toluene / 90 °C
5.2: bis(tri-tert-butyl)phosphine / 3 h / 20 - 90 °C
With
morpholine; pyridine; potassium phosphate; carbon tetrabromide; caesium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine;
tetrakis(triphenylphosphine) palladium(0);
In
methanol; ethanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;
