Technology Process of {2-[(2,4-Difluorophenyl)imino]-4-methyl-1,3-thiazolidin-4-yl}methanol
There total 8 articles about {2-[(2,4-Difluorophenyl)imino]-4-methyl-1,3-thiazolidin-4-yl}methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
C16H14BrN;
With
bis(η3-allyl-μ-chloropalladium(II)); potassium carbonate; triphenylphosphine;
In
toluene;
at 120 ℃;
Inert atmosphere;
With
sodium tetrahydroborate;
In
tetrahydrofuran;
at 20 ℃;
for 4h;
Inert atmosphere;
DOI:10.1021/ol301663h
- Guidance literature:
-
C16H14BrN;
With
bis(η3-allyl-μ-chloropalladium(II)); potassium carbonate; triphenylphosphine;
In
1,4-dioxane;
Reflux;
With
sodium tetrahydroborate;
In
1,4-dioxane;
at 20 ℃;
DOI:10.1021/ol301663h
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: potassium tert-butylate / tetrahydrofuran / 20 °C / Inert atmosphere
2.1: palladium on activated charcoal; hydrogen / ethyl acetate / 20 °C
3.1: water; sodium hydroxide / methanol / Reflux; Inert atmosphere
4.1: bis(η3-allyl-μ-chloropalladium(II)); potassium carbonate; triphenylphosphine / toluene / 120 °C / Inert atmosphere
4.2: 4 h / 20 °C / Inert atmosphere
With
bis(η3-allyl-μ-chloropalladium(II)); palladium on activated charcoal; potassium tert-butylate; water; hydrogen; potassium carbonate; triphenylphosphine; sodium hydroxide;
In
tetrahydrofuran; methanol; ethyl acetate; toluene;
1.1: Wittig olefination;
DOI:10.1021/ol301663h
