sodium alpha-bromo-p-toluenesulphonate

Base Information

• Chemical Name: sodium alpha-bromo-p-toluenesulphonate
• CAS No.: 32014-22-5
• Molecular Formula: C7H7 Br O3 S . Na
• Molecular Weight: 273.083
• Hs Code.: 2904909090
• Mol file: 32014-22-5.mol

Synonyms:Benzenesulfonicacid, 4-(bromomethyl)-, sodium salt (9CI); p-Toluenesulfonic acid, a-bromo-, sodium salt (8CI);4-(Bromomethyl)benzenesulfonic acid sodium salt; 4-Sodiosulfobenzyl bromide;Sodium 4-(bromomethyl)benzenesulfonate; Sodium p-(bromomethyl)benzenesulfonate

Chemical Property of sodium alpha-bromo-p-toluenesulphonate

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 62.75000
• Density: g/cm³
• LogP: 2.90900
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

SODIUM ALPHA-BROMO-PARA-TOLUENESULPHONATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of sodium alpha-bromo-p-toluenesulphonate

There total 4 articles about sodium alpha-bromo-p-toluenesulphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

Sodium; 4-hydroxymethyl-benzenesulfonate (73506-14-6) → sodium (4-bromomethyl)benzenesulfonate (32014-22-5)

Guidance literature:

With hydrogen bromide; In acetic acid; for 48h; Ambient temperature;

Reference yield:

ethanol (64-17-5) + 4-(bromomethyl)benzene-1-sulfonyl chloride (66176-39-4) → 4-sulfobenzyl chloride sodium salt + Na(1+)*C9H11O4S(1-) + sodium (4-bromomethyl)benzenesulfonate (32014-22-5)

Guidance literature:

ethanol; 4-(bromomethyl)benzene-1-sulfonyl chloride; In water; for 3h; Reflux;

With sodium hydroxide; In water;

Reference yield:

4-(aminomethyl)benzenesulfonic acid (2393-24-0) → sodium (4-bromomethyl)benzenesulfonate (32014-22-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / 0.04M CH₃COONa, CH₃COOH, NaNO₂ / H₂O / 1 h / 40 °C

2: 95 percent / 40 percent HBr / acetic acid / 48 h / Ambient temperature

With hydrogen bromide; sodium acetate; acetic acid; sodium nitrite; In water; acetic acid;

upstream raw materials:

Sodium; 4-hydroxymethyl-benzenesulfonate

4-(aminomethyl)benzenesulfonic acid

benzylamine

ethanol

Downstream raw materials:

Boc-Gln-Phe-Phe-OBzl-SO₃Na

Z-Tyr(Bzl)-Pro-Phe-OBzl-SO₃Na

N-ethyl-N-(4-sulfophenyl-methyl)-4-fluoro-3-methyl-aniline, sodium salt

4-({4-[(E)-2-(2,3,5,6,8,9,11,12-octahydro-1,4,7,10,13-benzopentaoxacyclopentadecin-15-yl)-1-ethenyl]-1-quinoliniumyl}methyl)-1-benzenesulfonate

Refernces

• 1、 Hubbuch, Arnulf,Bindewald, Roland,Foehles, Josef,Naithani, Vinod Kumar,Zahn, Helmut. "4-Sulfobenzyl, eine neue Carboxyschutzgruppe". . p. 394 - 395. Retrieved 2007/10/02.