Benzamide, N-(1,1-dimethylethyl)-2-(1-methylethenyl)-

Base Information

• Chemical Name: Benzamide, N-(1,1-dimethylethyl)-2-(1-methylethenyl)-
• CAS No.: 918867-78-4
• Molecular Formula: C14H19NO
• Molecular Weight: 217.311
• Mol file: 918867-78-4.mol

Synonyms:

Chemical Property of Benzamide, N-(1,1-dimethylethyl)-2-(1-methylethenyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzamide, N-(1,1-dimethylethyl)-2-(1-methylethenyl)-

There total 12 articles about Benzamide, N-(1,1-dimethylethyl)-2-(1-methylethenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

1-bromo-2-isopropenylbenzene (7073-70-3) + Tert-butyl isocyanate (1609-86-5) → N-(tert-butyl)-2-(prop-1-en-2-yl)benzamide (918867-78-4)

Guidance literature:

1-bromo-2-isopropenylbenzene; With n-butyllithium; In diethyl ether; hexane; at -78 - 20 ℃;

Tert-butyl isocyanate; In diethyl ether; hexane; at -78 - 20 ℃; Further stages.;

DOI:10.1021/jo0703909

Reference yield: 73.0%

→ N-(tert-butyl)-2-(prop-1-en-2-yl)benzamide (918867-78-4)

Guidance literature:

With 2-phenylpyridine; [RhCl₂(p-cymene)]2; potassium acetate; In water; 1,2-dichloro-ethane; for 48h; Schlenk technique; Inert atmosphere; Sealed tube; Irradiation;

Reference yield: 67.0%

1-bromo-1-propene (590-14-7) + N-t-butylbenzamide (5894-65-5) → N-(tert-butyl)-2-(prop-1-en-2-yl)benzamide (918867-78-4)

Guidance literature:

N-t-butylbenzamide; With lithium (tetra)butylmagnesate; In tetrahydrofuran; hexane; at 20 ℃; Inert atmosphere;

1-bromo-1-propene; With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; hexane; for 18h; Inert atmosphere; Reflux;

DOI:10.1039/c0cc01731k

upstream raw materials:

N-tert-butyl-2-cyclopropylbenzamide

1-bromo-2-isopropenylbenzene

Tert-butyl isocyanate

1-bromo-2-cyclopropylbenzene

Refernces

• 1、 Groendyke, Brian J.,Abusalim, Deyaa I.,Cook, Silas P.. "Iron-Catalyzed, Fluoroamide-Directed C-H Fluorination". . p. 12771 - 12774. Retrieved 2016/10/13.
• 2、 Jazzar, Rodolphe,Bourg, Jean-Baptiste,Dewhurst, Rian D.,Donnadieu, Bruno,Bertrand, Guy. "Intramolecular "hydroiminiumation and -amidiniumation" of alkenes: A convenient, flexible, and scalable route to cyclic iminium and imidazolinium salts". . p. 3492 - 3499. Retrieved 2008/02/03.