BENZHYDRYL B-CHLOROETHYL ETHER

Base Information

• Chemical Name: BENZHYDRYL B-CHLOROETHYL ETHER
• CAS No.: 32669-06-0
• Molecular Formula: C15H15ClO
• Molecular Weight: 246.737
• Hs Code.: 2909309090
• Mol file: 32669-06-0.mol

Synonyms:Ether,2-chloroethyl diphenylmethyl (6CI,8CI);1,1'-[(2-Chloroethoxy)methylene]bis[benzene];2-(Benzhydryloxy)-1-chloroethane;2-(Diphenylmethoxy)ethyl chloride;2-Chloroethyl diphenylmethyl ether;Benzhydryl 2-chloroethyl ether;b-Chloroethyl benzhydryl ether;

Chemical Property of BENZHYDRYL B-CHLOROETHYL ETHER

Chemical Property:

• Vapor Pressure: 0.000206mmHg at 25°C
• Refractive Index: 1.561
• Boiling Point: 337.4 °C at 760 mmHg
• Flash Point: 157 °C
• PSA: 9.23000
• Density: 1.119 g/cm³
• LogP: 4.03140
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Ethyl Acetate (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-ChloroethylBenzhydrylEther ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Diphenhydramine hydrochloride (D486900) related compound.

Technology Process of BENZHYDRYL B-CHLOROETHYL ETHER

There total 7 articles about BENZHYDRYL B-CHLOROETHYL ETHER which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

2-diphenylmethoxyethanol (26926-47-6) → 1,1'-[(2-chloroethoxy)methylene]bis-benzene (32669-06-0)

Guidance literature:

With tetrachloromethane; triphenylphosphine; In acetonitrile; for 4h; Ambient temperature;

DOI:10.1016/0223-5234(93)90042-D

Reference yield: 84.0%

1,1-Diphenylmethanol (91-01-0) + 2-chloro-ethanol (107-07-3) → 1,1'-[(2-chloroethoxy)methylene]bis-benzene (32669-06-0)

Guidance literature:

With toluene-4-sulfonic acid; In dichloromethane; Heating;

DOI:10.1002/adsc.200606183

Reference yield: 26.0%

Bromodiphenylmethane (776-74-9) + 2-chloro-ethanol (107-07-3) → 1,1'-[(2-chloroethoxy)methylene]bis-benzene (32669-06-0)

Guidance literature:

In toluene; for 24h; Reflux;

DOI:10.1016/j.ejmech.2016.01.059

upstream raw materials:

1,1-Diphenylmethanol

Bromodiphenylmethane

2-chloro-ethanol

2-diphenylmethoxyethanol

Downstream raw materials:

1-[2-(diphenylmethoxy)ethyl]piperazine

1,4-bis-(2-benzhydryloxy-ethyl)-piperazine

N,N-diethyl-N'-(2-benzhydryloxy-ethyl)-N'-methyl-ethylenediamine

ethyl-(2-benzhydryloxy-ethyl)-amine

Refernces

• 1、 Sanz, Roberto,Martinez, Alberto,Miguel, Delia,Alvarez-Gutierrez, Julia M.,Rodriguez, Felix. "Bronsted acid-catalyzed nucleophilic substitution of alcohols". . p. 1841 - 1845. Retrieved 2007/10/03.
• 2、 Lewis, David B.,Matecka, Dorota,Zhang, Ying,Hsin, Ling-Wei,Dersch, Christina M.,Stafford, David,Glowa, John R.,Rothman, Richard B.,Rice, Kenner C.. "Oxygenated analogues of 1-[2-(diphenylmethoxy)ethyl]- and 1- [2- [bis (4-fluorophenyl)methoxy]ethyl]-4-(3-phenylpropyl)piperazines (GBR 12935 and GBR 12909) as potential extended-action cocaine-abuse therapeutic agents". . p. 5029 - 5042. Retrieved 2007/10/03.