Technology Process of 1(4H)-Pyridinecarboxylic acid,
6-butyl-3-[(2,6-dichlorophenyl)methyl]-2-methyl-4-oxo-, phenylmethyl
ester
There total 7 articles about 1(4H)-Pyridinecarboxylic acid,
6-butyl-3-[(2,6-dichlorophenyl)methyl]-2-methyl-4-oxo-, phenylmethyl
ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-benzyloxycarbonyl-6-butyl-3-(2,6-dichlorobenzyl)-5,6-dihydro-2-methyl4-pyridone;
With
Phenylselenyl bromide; lithium hexamethyldisilazane;
In
tetrahydrofuran;
at -78 ℃;
for 1h;
With
3-chloro-benzenecarboperoxoic acid;
In
dichloromethane;
at 20 ℃;
for 1h;
Further stages.;
DOI:10.1016/j.bmc.2006.10.012
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 72 percent / sodium hydride / dimethylformamide / 6 h / 50 °C
2.1: tetrahydrofuran / 3 h / 20 °C
2.2: 56 percent / HCl / 1 h / 20 °C
3.1: lithium hexamethyldisilazide; phenylselenyl bromide / tetrahydrofuran / 1 h / -78 °C
3.2: 39 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / 20 °C
With
Phenylselenyl bromide; sodium hydride; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.10.012
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 94 percent / pyridine / 3 h / 20 °C
2.1: 87 percent / potassium tert-butoxide / tetrahydrofuran / 0.17 h / 20 °C
3.1: 72 percent / sodium hydride / dimethylformamide / 6 h / 50 °C
4.1: tetrahydrofuran / 3 h / 20 °C
4.2: 56 percent / HCl / 1 h / 20 °C
5.1: lithium hexamethyldisilazide; phenylselenyl bromide / tetrahydrofuran / 1 h / -78 °C
5.2: 39 percent / m-chloroperbenzoic acid / CH2Cl2 / 1 h / 20 °C
With
pyridine; Phenylselenyl bromide; potassium tert-butylate; sodium hydride; lithium hexamethyldisilazane;
In
tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2006.10.012
