4-(BENZYLOXY)-N,N-DIMETHYLPHENYLACETAMIDE

Base Information

• Chemical Name: 4-(BENZYLOXY)-N,N-DIMETHYLPHENYLACETAMIDE
• CAS No.: 919475-15-3
• Molecular Formula: C17H19NO2
• Molecular Weight: 269.343
• Hs Code.: 2924299090
• Mol file: 919475-15-3.mol

Synonyms:4-benzyloxy-N,N-dimethylbenzeneacetamide;

Chemical Property of 4-(BENZYLOXY)-N,N-DIMETHYLPHENYLACETAMIDE

Chemical Property:

• PSA: 29.54000
• LogP: 2.89630
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

99.9% ^*data from raw suppliers

2-(4-(Benzyloxy)phenyl)-N,N-dimethylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(4-(Benzyloxy)phenyl)-N,N-dimethylacetamide is a reactant used in the synthesis of O-desmethylvenlafaxine succinate.

Technology Process of 4-(BENZYLOXY)-N,N-DIMETHYLPHENYLACETAMIDE

There total 2 articles about 4-(BENZYLOXY)-N,N-DIMETHYLPHENYLACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

N,N-dimethyl-p-hydroxyphenylacetamide (76472-23-6) + benzyl bromide (100-39-0) → 2-(4-benzyloxy-phenyl)-N,N-dimethyl-acetamide (919475-15-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 - 60 ℃; for 97h;

Reference yield: 90.0%

2-[4-(benzyloxy)benzyl]acetic acid (6547-53-1) + N,N-dimethylammonium chloride (506-59-2) → 2-(4-benzyloxy-phenyl)-N,N-dimethyl-acetamide (919475-15-3)

Guidance literature:

2-[4-(benzyloxy)benzyl]acetic acid; With thionyl chloride; N,N-dimethyl-formamide; In dichloromethane; for 6h; Heating / reflux;

N,N-dimethylammonium chloride; With triethylamine; In dichloromethane; at 5 - 10 ℃; for 1h;

Reference yield: 96.0%

cyclohexanedione monoethylene ketal (4746-97-8) + 2-(4-benzyloxy-phenyl)-N,N-dimethyl-acetamide (919475-15-3) → C25H31NO5 (955365-82-9)

Guidance literature:

2-(4-benzyloxy-phenyl)-N,N-dimethyl-acetamide; With lithium diisopropyl amide; In tetrahydrofuran; at -78 - 0 ℃;

cyclohexanedione monoethylene ketal; In tetrahydrofuran; at -78 - 0 ℃; for 2h;

With water; ammonium chloride; In tetrahydrofuran;

upstream raw materials:

N,N-dimethyl-p-hydroxyphenylacetamide

benzyl bromide

2-[4-(benzyloxy)benzyl]acetic acid

N,N-dimethylammonium chloride

Downstream raw materials:

C₂₅H₃₁NO₅

1-[(4-benzyloxyphenyl)dimethylaminocarbonylmethyl]cyclohexanol

1-[2-(dimethylamino)-1-(4-benzyloxyphenyl)ethyl]cyclohexanol

Refernces

• 1、 -. "Highly selective serotonin and norepinephrine dual reuptake inhibitor and use thereof". Page/Page column 6; 10. . Retrieved 2010/11/25.