3-CHLORO-4-NITROANILINE

Base Information

• Chemical Name: 3-CHLORO-4-NITROANILINE
• CAS No.: 825-41-2
• Molecular Formula: C6H5ClN2O2
• Molecular Weight: 172.571
• Hs Code.: 2921420090
• Mol file: 825-41-2.mol

Synonyms:Aniline,3-chloro-4-nitro- (7CI,8CI);NSC 39966;3-Chloro-4-nitrobenzenamine;Aniline, 3-chloro-4-nitro-;

Chemical Property of 3-CHLORO-4-NITROANILINE

Chemical Property:

• Vapor Pressure: 1.42E-05mmHg at 25°C
• Melting Point: 158 °C
• Refractive Index: 1.646
• Boiling Point: 366.8 °C at 760 mmHg
• PKA: -0.06±0.10(Predicted)
• Flash Point: 175.7 °C
• PSA: 71.84000
• Density: 1.494 g/cm³
• LogP: 2.93480
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Water Solubility.: Insoluble in water.

Purity/Quality:

99% ^*data from raw suppliers

3-Chloro-4-nitroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 3-Chloro-4-nitroaniline is used as a pharmaceutical and medical intermediate.

Technology Process of 3-CHLORO-4-NITROANILINE

There total 13 articles about 3-CHLORO-4-NITROANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

2-Chloronitrobenzene (88-73-3) → 3-chloro-4-nitroaniline (825-41-2)

Guidance literature:

With potassium tert-butylate; N,N-tetramethylene-thiocarbamoyl-sulphenamide; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

DOI:10.1021/jo970582b

Reference yield: 72.0%

3-chloro-aniline (108-42-9) → 3-chloro-4-nitroaniline (825-41-2)

Guidance literature:

With sulfuric acid; uronium nitrate; at 0 - 10 ℃; for 0.5h;

Reference yield: 60.0%

2-Chloronitrobenzene (88-73-3) + N,N-tetramethylene-thiocarbamoyl-sulphenamide (118535-52-7) → 3-chloro-4-nitroaniline (825-41-2) + 2-nitro-N-(N,N-tetramethylenethiocarbamoylthio)aniline

Guidance literature:

With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;

DOI:10.1021/jo970582b

upstream raw materials:

3-Chloroacetanilide

3-chloro-4-nitroacetanilide

3-chloro-aniline

2-Chloronitrobenzene

Downstream raw materials:

benzoic acid-(3-chloro-4-nitro-anilide)

3-chloro-4-nitroacetanilide

5-chloro-6-nitroquinoline

7-chloro-6-nitroquinoline

Refernces

• 1、 -. "PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS". . . Retrieved 2012/02/01.
• 2、 Makosza, Mieczyslaw,Bialecki, Maciej. "Nitroarylamines via the Vicarious Nucleophilic Substitution of Hydrogen: Amination, Alkylamination, and Arylamination of Nitroarenes with Sulfenamides". . p. 4878 - 4888. Retrieved 2007/10/03.