2,5-DIMETHOXYBENZENESULFONYL CHLORIDE

Base Information

• Chemical Name: 2,5-DIMETHOXYBENZENESULFONYL CHLORIDE
• CAS No.: 1483-28-9
• Molecular Formula: C8H9ClO4S
• Molecular Weight: 236.676
• Hs Code.: 29093090
• Mol file: 1483-28-9.mol

Synonyms:2,5-Bis(methyloxy)benzenesulfonylchloride;2,5-Dimethoxybenzene-1-sulfonyl chloride;2,5-Dimethoxyphenylsulfonyl chloride;

Chemical Property of 2,5-DIMETHOXYBENZENESULFONYL CHLORIDE

Chemical Property:

• Appearance/Colour: yellow crystals or crystalline powder
• Vapor Pressure: 4.85E-05mmHg at 25°C
• Melting Point: 112-116 °C(lit.)
• Refractive Index: 1.522
• Boiling Point: 359.7 °C at 760 mmHg
• Flash Point: 171.3 °C
• PSA: 60.98000
• Density: 1.359 g/cm³
• LogP: 2.71210
• Storage Temp.: 2-8°C
• Sensitive.: Moisture Sensitive

Purity/Quality:

99% ^*data from raw suppliers

2,5-Dimethoxybenzenesulfonyl chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 2,5-DIMETHOXYBENZENESULFONYL CHLORIDE

There total 3 articles about 2,5-DIMETHOXYBENZENESULFONYL CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.56%

1,4-dimethoxybezene (150-78-7) → 2,5-dimethoxybenzene-1-sulfonyl chloride (1483-28-9)

Guidance literature:

With chlorosulfonic acid; at 0 - 5 ℃;

DOI:10.1007/s00044-017-1858-1

Reference yield:

Potassium; 2,5-dimethoxy-benzenesulfonate (143018-66-0) → 2,5-dimethoxybenzene-1-sulfonyl chloride (1483-28-9)

Guidance literature:

With phosphorus pentachloride;

DOI:10.1021/jo01016a044

Reference yield:

→ 2,5-dimethoxybenzene-1-sulfonyl chloride (1483-28-9)

Guidance literature:

upstream raw materials:

1,4-dimethoxybezene

Potassium; 2,5-dimethoxy-benzenesulfonate

Downstream raw materials:

2,5-dimethoxy-benzenesulfonic acid 2-amino-3-methyl-phenyl ester

2,5-dimethoxythiophenol

C₁₁H₁₆N₂O₆S

Refernces

• 1、 Kornahrens, Anne F.,Cognetta, Armand B.,Brody, Daniel M.,Matthews, Megan L.,Cravatt, Benjamin F.,Boger, Dale L.. "Design of Benzoxathiazin-3-one 1,1-Dioxides as a New Class of Irreversible Serine Hydrolase Inhibitors: Discovery of a Uniquely Selective PNPLA4 Inhibitor". supporting information. p. 7052 - 7061. Retrieved 2017/05/31.
• 2、 Gallardo-Godoy, Alejandra,Fierro, Angélica,McLean, Thomas H.,Castillo, Mariano,Cassels, Bruce K.,Reyes-Parada, Miguel,Nichols, David E.. "Sulfur-substituted α-alkyl phenethylamines as selective and reversible MAO-A inhibitors: Biological activities, CoMFA analysis, and active site modeling". . p. 2407 - 2419. Retrieved 2007/10/03.