3-METHYLISOQUINOLINE 2-OXIDE

Base Information

• Chemical Name: 3-METHYLISOQUINOLINE 2-OXIDE
• CAS No.: 14548-00-6
• Molecular Formula: C10H9 N O
• Molecular Weight: 159.188
• Hs Code.: 2933499090
• Mol file: 14548-00-6.mol

Synonyms:3-MethylisoquinolineN-oxide; NSC 338441

Chemical Property of 3-METHYLISOQUINOLINE 2-OXIDE

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 25.46000
• Density: g/cm³
• LogP: 2.57670

Purity/Quality:

99% ^*data from raw suppliers

3-METHYLISOQUINOLIN-2-IUM-2-OLATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-METHYLISOQUINOLINE 2-OXIDE

There total 3 articles about 3-METHYLISOQUINOLINE 2-OXIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

3-methylisoquinoline (1125-80-0) → 3-methylisoquinoline N-oxide (14548-00-6)

Guidance literature:

With dihydrogen peroxide; methyltrioxorhenium(VII); In dichloromethane; at 20 ℃;

DOI:10.1021/ja710451s

Reference yield: 66.0%

3-methylisoquinoline (1125-80-0) + m-chloroperoxybenzoic acid (64741-01-1) → 3-methylisoquinoline N-oxide (14548-00-6)

Guidance literature:

In dichloromethane; at 20 ℃; for 48h;

Reference yield:

→ 3-methylisoquinoline N-oxide (14548-00-6)

Guidance literature:

DOI:10.1021/ja01055a011

upstream raw materials:

3-methylisoquinoline

m-chloroperoxybenzoic acid

Downstream raw materials:

3-methylisoquinolone

(3-methylisoquinolin-1-yl)(phenyl)methanone

1-chloro-3-methyl-isoquinoline

3-methyl-1-p-tolylisoquinoline 2-oxide

Refernces

• 1、 Bertuzzi, Giulio,Pecorari, Daniel,Bernardi, Luca,Fochi, Mariafrancesca. "An organocatalytic enantioselective direct α-heteroarylation of aldehydes with isoquinoline: N -oxides". supporting information. p. 3977 - 3980. Retrieved 2018/04/23.
• 2、 Qiao, Kai,Wan, Li,Sun, Xiaoning,Zhang, Kai,Zhu, Ning,Li, Xin,Guo, Kai. "Regioselective Chlorination of Quinoline N-Oxides and Isoquinoline N-Oxides Using PPh3/Cl3CCN". . p. 1606 - 1611. Retrieved 2016/04/05.