Einecs 263-767-2

Base Information

• Chemical Name: Einecs 263-767-2
• CAS No.: 62942-43-2
• Molecular Formula: C20H18ClOP
• Molecular Weight: 340.789
• Hs Code.: 29319090
• DSSTox Substance ID: DTXSID80978778
• Mol file: 62942-43-2.mol

Synonyms:EINECS 263-767-2;SCHEMBL6046249;DTXSID80978778;AKOS015917553;(2-Oxoethyl)(triphenyl)phosphanium bromide;D90661

Chemical Property of Einecs 263-767-2

Chemical Property:

• Appearance/Colour: yellow Powder
• Melting Point: 209-212 °C (dec.)(lit.)
• PSA: 30.66000
• LogP: 0.18340
• Storage Temp.: 2-8°C
• Sensitive.: Hygroscopic
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 5
• Exact Mass: 384.02786
• Heavy Atom Count: 23
• Complexity: 290

Purity/Quality:

99% ^*data from raw suppliers

(Formylmethyl)triphenylphosphonium Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,C
• Statements: 22-41-34
• Safety Statements: 26-39-45-36/37/39-27

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=CC=C(C=C1)[P+](CC=O)(C2=CC=CC=C2)C3=CC=CC=C3.[Br-]
• Uses: Reactant for:? ;Hydroazidation reactions in preparation of a-azido alcohols1? ;Preparation of prodrug (2-hydroxyamino-vinyl)-triphenyl-phosphonium (HVTP) inhibitor of peroxidase activity and apoptosis2? ;Intramolecular [4 + 3] cycloaddition reactions3 (Formylmethyl)triphenylphosphonium Chloride is a useful Wittig reagent. Used as a reactant for Hydroazidation reactions in preparation of a-azido alcohols, Preparation of prodrug (2-hydroxyamino-vinyl)-triphenyl-phosphonium (HVTP) inhibitor of peroxidase activity and apoptosis and Intramolecular [4 + 3] cycloaddition reactions.

Technology Process of Einecs 263-767-2

There total 3 articles about Einecs 263-767-2 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.5%

2-chloroethanal (107-20-0) + triphenylphosphine (603-35-0) → formylmethyltriphenylphosphonium chloride (62942-43-2)

Guidance literature:

In acetic acid butyl ester; water; for 8h; under 637.564 Torr; Solvent; Reflux;

Reference yield:

C22H24O2P(1+)*Cl(1-) → formylmethyltriphenylphosphonium chloride (62942-43-2)

Guidance literature:

With sulfuric acid; water; at 40 ℃; for 2h; Reagent/catalyst;

Reference yield:

triphenylphosphine (603-35-0) → formylmethyltriphenylphosphonium chloride (62942-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 10 h / 80 °C

2: sulfuric acid; water / 2 h / 40 °C

With sulfuric acid; water;

upstream raw materials:

2-chloroethanal

triphenylphosphine

Downstream raw materials:

C₂₀H₂₅NO₇

4-methyl-N-{2-[2-(triphenyl-λ⁵-phosphanylidene)-ethylideneamino]-phenyl}-benzenesulfonamide

(2-azido-2-hydroxyethyl)triphenylphosphonium chloride

(E)-3-([1,1′-biphenyl]-4-yl)acrylaldehyde

Refernces

• 1、 -. "Method for preparing (formylmethylene)triphenylphosphorane". Paragraph 0006-0008; 0011-0013; 0016-0018; 0021-0023; 0026. . Retrieved 2019/10/01.