3(2H)-Pyridazinone,6-[4-[2-(acetyloxy)ethyl]-2,6-dichlorophenoxy]-2-methyl-4-(1-methylethyl)-

Base Information

• Chemical Name: 3(2H)-Pyridazinone,6-[4-[2-(acetyloxy)ethyl]-2,6-dichlorophenoxy]-2-methyl-4-(1-methylethyl)-
• CAS No.: 920509-38-2
• Molecular Formula: C18H20Cl2N2O4
• Molecular Weight: 399.274
• Mol file: 920509-38-2.mol

Synonyms:

Chemical Property of 3(2H)-Pyridazinone,6-[4-[2-(acetyloxy)ethyl]-2,6-dichlorophenoxy]-2-methyl-4-(1-methylethyl)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3(2H)-Pyridazinone,6-[4-[2-(acetyloxy)ethyl]-2,6-dichlorophenoxy]-2-methyl-4-(1-methylethyl)-

There total 4 articles about 3(2H)-Pyridazinone,6-[4-[2-(acetyloxy)ethyl]-2,6-dichlorophenoxy]-2-methyl-4-(1-methylethyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3,5-dichloro-4-hydroxyphenyl)ethanol (115150-58-8) → 3,5-dichloro-4-((5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenylethyl acetate (920509-38-2)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium tert-butylate / N,N-dimethyl acetamide / 24 h / 20 - 135 °C

2: sodium acetate / 24 h / 114 °C

3: potassium carbonate / 28 h / 20 - 40 °C

With potassium tert-butylate; sodium acetate; potassium carbonate; In N,N-dimethyl acetamide;

DOI:10.1021/jm4019299

Reference yield:

(3,5-dichloro-4-hydroxyphenyl)acetic acid methyl ester (409366-27-4) → 3,5-dichloro-4-((5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenylethyl acetate (920509-38-2)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0.08 h / -10 °C / Inert atmosphere

2: potassium tert-butylate / N,N-dimethyl acetamide / 24 h / 20 - 135 °C

3: sodium acetate / 24 h / 114 °C

4: potassium carbonate / 28 h / 20 - 40 °C

With lithium aluminium tetrahydride; potassium tert-butylate; sodium acetate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl acetamide;

DOI:10.1021/jm4019299

Reference yield:

Methyl 4-hydroxyphenylacetate (14199-15-6) → 3,5-dichloro-4-((5-isopropyl-1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenylethyl acetate (920509-38-2)

Guidance literature:

Multi-step reaction with 5 steps

1: diisobutylamine; sulfuryl dichloride / toluene / 1.5 h / 20 - 70 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0.08 h / -10 °C / Inert atmosphere

3: potassium tert-butylate / N,N-dimethyl acetamide / 24 h / 20 - 135 °C

4: sodium acetate / 24 h / 114 °C

5: potassium carbonate / 28 h / 20 - 40 °C

With lithium aluminium tetrahydride; diisobutylamine; sulfuryl dichloride; potassium tert-butylate; sodium acetate; potassium carbonate; In tetrahydrofuran; N,N-dimethyl acetamide; toluene;

DOI:10.1021/jm4019299

upstream raw materials:

Methyl 4-hydroxyphenylacetate

(3,5-dichloro-4-hydroxyphenyl)acetic acid methyl ester

2-(3,5-dichloro-4-hydroxyphenyl)ethanol

2-[3,5-dichloro-4-(6-chloro-5-isopropylpyridazin-3-yloxy)phenyl]ethanol

Downstream raw materials:

6-[2,6-dichloro-4-(2-hydroxyethyl)phenoxy]-4-isopropyl-2-methylpyridazin-3-one

Refernces