3,4-Dimethoxybenzohydrazide

Base Information

• Chemical Name: 3,4-Dimethoxybenzohydrazide
• CAS No.: 41764-74-3
• Molecular Formula: C9H12 N2 O3
• Molecular Weight: 196.206
• Hs Code.: 2928000090
• European Community (EC) Number: 255-541-7
• UNII: 2DJ9HKF6NG
• DSSTox Substance ID: DTXSID50194589
• Nikkaji Number: J278.271E
• Wikidata: Q69754404
• ChEMBL ID: CHEMBL453750
• Mol file: 41764-74-3.mol

Synonyms:3,4-dimethoxybenzohydrazide;41764-74-3;3,4-Dimethoxybenzhydrazide;Veratrohydrazide;3,4-Dimethoxybenzenecarbohydrazide;2DJ9HKF6NG;EINECS 255-541-7;UNII-2DJ9HKF6NG;3,4-Dimethoxybenzoic acid hydrazide;1,2-dimethoxybenzene-4-carbohydrazide;veratric acid hydrazide;Oprea1_111717;CHEMBL453750;SCHEMBL2446906;DTXSID50194589;JS-126C;AMY15158;BBL002134;MFCD00017061;STK123264;AKOS000265248;SB86018;FT-0614340;FT-0614341;EN300-03667;H10407;A825650;A828735;J-511213;Z56876392;F1099-0056

Chemical Property of 3,4-Dimethoxybenzohydrazide

Chemical Property:

• Melting Point: 145-146°C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 73.58000
• Density: 1.189g/cm³
• LogP: 1.39850
• XLogP3: 0.6
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 3
• Exact Mass: 196.08479225
• Heavy Atom Count: 14
• Complexity: 199

Purity/Quality:

98%min ^*data from raw suppliers

3,4-Dimethoxybenzhydrazide ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=C(C=C(C=C1)C(=O)NN)OC
• Recent ClinicalTrials: Dose-finding Study of WS6788A, DS37-4 and H10407 Enterotoxigenic Escherichia Coli (ETEC) Challenge Strains

Technology Process of 3,4-Dimethoxybenzohydrazide

There total 7 articles about 3,4-Dimethoxybenzohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

ethyl veratrate (3943-77-9) → 3,4-dimethoxybenzohydrazide (41764-74-3)

Guidance literature:

With hydrazine hydrate; In ethanol; for 18h; Reflux;

DOI:10.1002/ejoc.201900743

Reference yield: 94.5%

methyl 3,4-dimethoxybenzoate (2150-38-1) → 3,4-dimethoxybenzohydrazide (41764-74-3)

Guidance literature:

With hydrazine;

Reference yield: 88.0%

Veratric acid (93-07-2) → 3,4-dimethoxybenzohydrazide (41764-74-3)

Guidance literature:

With hydrazine hydrate; for 0.0416667h; Microwave irradiation;

upstream raw materials:

methyl 3,4-dimethoxybenzoate

ethyl veratrate

Veratric acid

3,4-dimethoxybenzoic acid chloride

Downstream raw materials:

3,4-dimethoxybenzoyl azide

3,4-dimethoxy-benzoic acid veratrylidenehydrazide

N-[5-(3,4-dimethoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-benzenesulfonamide

2-(3,4-dimethoxyphenyl)-1,3,4-oxadiazole

Refernces

• 1、 Al-Wahaibi, Lamya H.,Mohamed, Ahmed A. B.,Tawfik, Samar S.,Hassan, Hanan M.,El-Emam, Ali A.. "1,3,4-oxadiazole n-mannich bases: Synthesis, antimicrobial, and anti-proliferative activities". . . Retrieved 2021/05/26.
• 2、 -. "COMPOUNDS HAVING EXCITED STATE INTRAMOLECULAR PROTON TRANSFER (ESIPT) CHARACTER FOR USE IN TREATING AND/OR PREVENTING SUNBURN AND/OR PREVENTING U.V. DAMAGE". Page/Page column 36. . Retrieved 2020/09/27.