Technology Process of 3-Quinolinecarboxylic acid,
4-[[4-(3,4-dimethyl-1-piperazinyl)phenyl]amino]-6-fluoro-, ethyl ester
There total 9 articles about 3-Quinolinecarboxylic acid,
4-[[4-(3,4-dimethyl-1-piperazinyl)phenyl]amino]-6-fluoro-, ethyl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: 58 percent / K2CO3 / dimethylsulfoxide / 80 °C
2.1: aq. NaOH; TBAI / toluene / 0.5 h / 60 °C
2.2: 72 percent / TBAI / aq. NaOH; toluene / 1.5 h / 60 °C
3.1: 80 percent / hydrazine hydrate / Pd/C / Heating
4.1: 123 mg / p-TsOH*H2O / methanol / 0.33 h / 125 °C / microwave irradiation
With
sodium hydroxide; tetra-(n-butyl)ammonium iodide; potassium carbonate; toluene-4-sulfonic acid; hydrazine hydrate;
palladium on activated charcoal;
In
methanol; dimethyl sulfoxide; toluene;
DOI:10.1021/jm060262x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: aq. NaOH; TBAI / toluene / 0.5 h / 60 °C
1.2: 72 percent / TBAI / aq. NaOH; toluene / 1.5 h / 60 °C
2.1: 80 percent / hydrazine hydrate / Pd/C / Heating
3.1: 123 mg / p-TsOH*H2O / methanol / 0.33 h / 125 °C / microwave irradiation
With
sodium hydroxide; tetra-(n-butyl)ammonium iodide; toluene-4-sulfonic acid; hydrazine hydrate;
palladium on activated charcoal;
In
methanol; toluene;
DOI:10.1021/jm060262x
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 80 percent / hydrazine hydrate / Pd/C / Heating
2: 123 mg / p-TsOH*H2O / methanol / 0.33 h / 125 °C / microwave irradiation
With
toluene-4-sulfonic acid; hydrazine hydrate;
palladium on activated charcoal;
In
methanol;
DOI:10.1021/jm060262x