methyl 3-oxopropanoate

Base Information

• Chemical Name: methyl 3-oxopropanoate
• CAS No.: 63857-17-0
• Molecular Formula: C4H6O3
• Molecular Weight: 102.09
• Hs Code.: 2918300090
• Mol file: 63857-17-0.mol

Synonyms:Malonaldehydicacid, methyl ester (6CI);Methyl 2-formylacetate;

Chemical Property of methyl 3-oxopropanoate

Chemical Property:

• Vapor Pressure: 9.07mmHg at 25°C
• Refractive Index: 1.388
• Boiling Point: 131.934 °C at 760 mmHg
• PKA: 7.05±0.23(Predicted)
• Flash Point: 39.507 °C
• PSA: 43.37000
• Density: 1.071 g/cm³
• LogP: -0.25160

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 3-oxopropanoate

There total 3 articles about methyl 3-oxopropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

(E)-methyl 3-(1-phenylethoxy)acrylate (147514-81-6) → methyl 3-oxopropionate (63857-17-0) + 1-Phenylethanol (98-85-1,13323-81-4)

Guidance literature:

With water; dichloro bis(acetonitrile) palladium(II); at 40 ℃; for 21h;

DOI:10.1016/j.jorganchem.2006.06.045

Reference yield: 26.9%

trans-9-phenylselenoxanthene 10-oxide (82238-33-3) + propynoic acid methyl ester (922-67-8) → methyl 3-oxopropionate (63857-17-0) + 9-phenylselenoxanthenol (30571-10-9) + methyl 9-phenylselenoxanthen-9-ylpropiolate (85891-62-9) + 3-Oxo-2-(9-phenyl-9H-10λ4-selenoxanthen-10-ylidene)-propionic acid methyl ester

Guidance literature:

In dichloromethane; Further byproducts given; Heating;

DOI:10.1016/S0040-4039(00)81331-3

Reference yield:

methanol (67-56-1) + cyclopenta-1,3-diene (542-92-7,25568-84-7,7313-32-8) → malonaldehydebis(dimethylacetal) (102-52-3) + methyl 3-oxopropionate (63857-17-0) + 3t-methoxy-propenal (78923-06-5) + 3,3-dimethoxypropanal (19060-10-7)

Guidance literature:

With 2,3-dimercapto-succinic acid; ozone; Yield given. Multistep reaction. Yields of byproduct given; 1) -78 deg C;

DOI:10.1021/jo00311a021

upstream raw materials:

methanol

cyclopenta-1,3-diene

trans-9-phenylselenoxanthene 10-oxide

propynoic acid methyl ester

Downstream raw materials:

3-(2,6-dichloro-phenyl)-isoxazole-4-carboxylic acid

methyl 3-methoxyprop-2-enoate

4-carbomethoxy-3-(3-cyanophenyl)isoxazole

Refernces

• 1、 Griesbaum, Karl,Jung, In Chang,Mertens, Henri. "Difunctional and Hetercyclic Prducts from the Ozonolysis of Conjugated C5-C8 Cyclodienes". . p. 6024 - 6027. Retrieved 2007/10/02.