2-b]pyridine

Base Information

• Chemical Name: 2-b]pyridine
• CAS No.: 92404-63-2
• Molecular Formula: C7H4BrNO
• Molecular Weight: 198.01700
• Mol file: 92404-63-2.mol

Synonyms:3-bromofuro<3,2-b>pyridine;

Chemical Property of 2-b]pyridine

Chemical Property:

• Melting Point: 51-53℃
• Boiling Point: 256.0±20.0 °C(Predicted)
• PKA: 1.97±0.40(Predicted)
• PSA: 26.03000
• Density: 1.710±0.06 g/cm3(Predicted)
• LogP: 2.59030

Purity/Quality:

98% ^*data from raw suppliers

3-bromofuro[3,2-b]pyridine 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 3-Bromofuro[3,2-b]pyridine is used as a starting material for synthesis of polyheterocycles.

Technology Process of 2-b]pyridine

There total 3 articles about 2-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

trans-2,3-dibromo-2,3-dihydrofuro<3,2-b>pyridine (92404-62-1) → 3-bromofuro<3,2-b>pyridine (92404-63-2)

Guidance literature:

With sodium hydroxide; In methanol; water;

Reference yield:

furo[3,2-b]pyridine (272-62-8) → 2-bromofuro[3,2-b]pyridine (344353-97-5) + 3-bromofuro<3,2-b>pyridine (92404-63-2)

Guidance literature:

furo[3,2-b]pyridine; With n-butyllithium; In diethyl ether; at -78 ℃; for 1h;

With carbon tetrabromide; In diethyl ether; at -95 ℃; for 1h; Further stages.;

DOI:10.1016/j.tet.2008.09.008

Reference yield:

furo[3,2-b]pyridine (272-62-8) → 3-bromofuro<3,2-b>pyridine (92404-63-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 92 percent / Br₂ / CCl₄

2: 100 percent / NaOH / methanol; H₂O

With sodium hydroxide; bromine; In methanol; tetrachloromethane; water;

upstream raw materials:

trans-2,3-dibromo-2,3-dihydrofuro<3,2-b>pyridine

furo[3,2-b]pyridine

Downstream raw materials:

2-ethynyl-3-pyridinol

2-(2-formyl-1-pentenyl)furo<3,2-b>pyridine

Furo[3,2-b]pyridine-3-carboxylic acid amide

2-phenylthio-3-bromofuro<3,2-b>pyridine

Refernces

• 1、 Shiotani, Shunsaku,Morita, Hiroyuki. "TYPICAL ELECTROPHILIC REACTIONS OF FUROPYRIDINES". . p. 738. Retrieved 2007/10/02.