4-CHLORO-4'-NITROBENZANILIDE

Base Information

• Chemical Name: 4-CHLORO-4'-NITROBENZANILIDE
• CAS No.: 39193-07-2
• Molecular Formula: C13H9ClN2O3
• Molecular Weight: 276.679
• Hs Code.: 2924299090
• Mol file: 39193-07-2.mol

Synonyms:Benzanilide,4-chloro-4'-nitro;(p-Chlorbenzoyl)-p-nitranilid;N-(p-Nitrophenyl)-p-chlorbenzoesaeureamid;4-chloro-benzoic acid-(4-nitro-anilide);N-(p-chlorobenzoyl)-p-nitroaniline;4-chloro-N-(4-nitrophenyl)-benzamide;4-Chlor-benzoesaeure-(4-nitro-anilid);

Chemical Property of 4-CHLORO-4'-NITROBENZANILIDE

Chemical Property:

• Vapor Pressure: 1.5E-05mmHg at 25°C
• Boiling Point: 366.1°Cat760mmHg
• Flash Point: 175.2°C
• PSA: 74.92000
• Density: 1.44g/cm³
• LogP: 4.09670

Purity/Quality:

99% ^*data from raw suppliers

4-CHLORO-4'-NITROBENZANILIDE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-CHLORO-4'-NITROBENZANILIDE

There total 17 articles about 4-CHLORO-4'-NITROBENZANILIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

nitrobenzene (98-95-3,26969-40-4) + 4-chlorobenzamide (619-56-7) → N-(4-nitrophenyl)-4-chlorophenyl carboxamide (39193-07-2) + trans-azoxybenzene (20972-43-4,21650-65-7,495-48-7,55599-32-1)

Guidance literature:

With tetramethyl ammoniumhydroxide; at 70 ℃; for 4h; under 40 Torr;

DOI:10.1021/jo00076a059

Reference yield: 93.0%

4-chloro-benzoyl chloride (122-01-0) + 4-nitro-aniline (100-01-6,104810-17-5) → N-(4-nitrophenyl)-4-chlorophenyl carboxamide (39193-07-2)

Guidance literature:

With triethylamine; In ethyl acetate; at 20 ℃; for 16h;

DOI:10.1002/cmdc.201800815

Reference yield: 82.0%

4-chlorobenzaldehyde (104-88-1) + 4-nitro-aniline (100-01-6,104810-17-5) → N-(4-nitrophenyl)-4-chlorophenyl carboxamide (39193-07-2)

Guidance literature:

With potassium bromate; In water; at 80 ℃; Microwave irradiation;

DOI:10.1007/s10562-019-02878-5

upstream raw materials:

4-chloro-benzoyl chloride

4-nitro-aniline

N-(p-Chlorobenzoyl)-p-methylbenzylamine

N¹-(p-chlorobenzoyl)-N¹,N²-di(p-nitrophenyl)formamidine

Downstream raw materials:

C₂₆H₁₆Cl₂N₄O₄S₂

4-chloro-N-(4-nitrophenyl)thiobenzamide

N-(4-aminophenyl)-4-chlorophenyl carboxamide

5-(4-chlorophenyl)-1-(4-nitrophenyl)tetrazole

Refernces

• 1、 Wang, Ru,Liu, Hu,You, Yuan-Yuan,Wang, Xin-Yu,Lv, Bing-Bing,Cao, Li-Qin,Xue, Jia-Yu,Xu, Yun-Gen,Shi, Lei. "Discovery of novel VEGFR-2 inhibitors embedding 6,7-dimethoxyquinazoline and diarylamide fragments". supporting information. . Retrieved 2021/02/02.
• 2、 Rustler, Karin,Pockes, Steffen,K?nig, Burkhard. "Light-Switchable Antagonists for the Histamine H1 Receptor at the Isolated Guinea Pig Ileum". . p. 636 - 644. Retrieved 2019/02/14.