3-Indolizinecarboxylic acid, 1-benzoyl-7-cyano-2-phenyl-, methyl ester

Base Information

• Chemical Name: 3-Indolizinecarboxylic acid, 1-benzoyl-7-cyano-2-phenyl-, methyl ester
• CAS No.: 928168-66-5
• Molecular Formula: C24H16N2O3
• Molecular Weight: 380.403
• Mol file: 928168-66-5.mol

Synonyms:

Chemical Property of 3-Indolizinecarboxylic acid, 1-benzoyl-7-cyano-2-phenyl-, methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3-Indolizinecarboxylic acid, 1-benzoyl-7-cyano-2-phenyl-, methyl ester

There total 1 articles about 3-Indolizinecarboxylic acid, 1-benzoyl-7-cyano-2-phenyl-, methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-cyano-1-(methoxycarbonylmethyl)pyridinium bromide + benzalacetophenone (94-41-7) → methyl 1-benzoyl-7-cyano-2-phenyl-indolizine-3-carboxylate (928168-66-5)

Guidance literature:

With manganese(IV) oxide; triethylamine; In toluene; at 90 ℃;

DOI:10.1016/j.ejps.2006.09.006

Reference yield: 90.0%

methyl 1-benzoyl-7-cyano-2-phenyl-indolizine-3-carboxylate (928168-66-5) → 1-benzoyl-2-phenyl-indolizine-7-carbonitrile (35247-33-7)

Guidance literature:

With sodium chloride; In water; dimethyl sulfoxide; at 150 ℃; for 20h;

DOI:10.1016/j.ejps.2006.09.006

Reference yield:

methyl 1-benzoyl-7-cyano-2-phenyl-indolizine-3-carboxylate (928168-66-5) → 1-(hydroxy-phenyl-methyl)-2-phenyl-indolizine-7-carbonitrile (928168-67-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / NaCl / dimethylsulfoxide; H₂O / 20 h / 150 °C

2: 85 percent / sodium borohydride / ethanol / 48 h / 20 °C

With sodium tetrahydroborate; sodium chloride; In ethanol; water; dimethyl sulfoxide;

DOI:10.1016/j.ejps.2006.09.006

upstream raw materials:

benzalacetophenone

Downstream raw materials:

1-benzoyl-2-phenyl-indolizine-7-carbonitrile

1-(hydroxy-phenyl-methyl)-2-phenyl-indolizine-7-carbonitrile

Refernces