2-Propenoic acid, 2-methyl-3-phenyl-, butyl ester

Base Information

• Chemical Name: 2-Propenoic acid, 2-methyl-3-phenyl-, butyl ester
• CAS No.: 92863-46-2
• Molecular Formula: C14H18O2
• Molecular Weight: 218.296
• Mol file: 92863-46-2.mol

Synonyms:

Chemical Property of 2-Propenoic acid, 2-methyl-3-phenyl-, butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Propenoic acid, 2-methyl-3-phenyl-, butyl ester

There total 16 articles about 2-Propenoic acid, 2-methyl-3-phenyl-, butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

chlorobenzene (108-90-7) + 2-methyl-butyl acrylate (97-88-1,9003-63-8) → (E)-2-methyl-3-phenylacrylic acid butyl ester (92863-46-2)

Guidance literature:

With bis(tri-t-butylphosphine)palladium⁽⁰⁾; N-Methyldicyclohexylamine; In toluene; at 20 - 100 ℃; for 22h; stereoselective reaction; Inert atmosphere;

DOI:10.15227/orgsyn.081.0063

Reference yield: 94.0%

butyl (E)-2-methyl-3-(p-toluenesulfonyloxy)prop-2-enoate (1188274-48-7) + phenylboronic acid (98-80-6) → (E)-2-methyl-3-phenylacrylic acid butyl ester (92863-46-2)

Guidance literature:

With palladium diacetate; sodium carbonate; tricyclohexylphosphine; In N,N-dimethyl-formamide; at 150 - 155 ℃; for 2h; Inert atmosphere;

DOI:10.1021/ol9013359

Reference yield: 91.0%

(E)-3-phenyl-2-methyl-2-propenol (1504-55-8,39924-63-5,55131-20-9) + butan-1-ol (71-36-3) → (E)-2-methyl-3-phenylacrylic acid butyl ester (92863-46-2)

Guidance literature:

With manganese(IV) oxide; triazolium salt; 1,8-diazabicyclo[5.4.0]undec-7-ene; at 20 ℃;

DOI:10.1021/ol062940f

upstream raw materials:

bromobenzene

2-methyl-butyl acrylate

iodobenzene

(E)-3-phenyl-2-methyl-2-propenol

Refernces

• 1、 -. "Preparation method of inactive alkene aryl compound". Paragraph 0075; 0076. . Retrieved 2019/06/05.
• 2、 Liu, Jie,Liu, Qiang,Franke, Robert,Jackstell, Ralf,Beller, Matthias. "Ligand-Controlled Palladium-Catalyzed Alkoxycarbonylation of Allenes: Regioselective Synthesis of α,β- and β,γ-Unsaturated Esters". supporting information. p. 8556 - 8563. Retrieved 2015/07/15.