Benzene, 1-(2-iodoethyl)-3,5-dimethyl-

Base Information

• Chemical Name: Benzene, 1-(2-iodoethyl)-3,5-dimethyl-
• CAS No.: 928775-73-9
• Molecular Formula: C₁₀H₁₃I
• Molecular Weight: 260.118
• Mol file: 928775-73-9.mol

Synonyms:

Chemical Property of Benzene, 1-(2-iodoethyl)-3,5-dimethyl-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Benzene, 1-(2-iodoethyl)-3,5-dimethyl-

There total 2 articles about Benzene, 1-(2-iodoethyl)-3,5-dimethyl- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

β-(3,5-Dimethylphenyl)ethyl alcohol (62343-67-3) → 1-(2-iodo-ethyl)-3,5-dimethyl-benzene (928775-73-9)

Guidance literature:

With 1H-imidazole; iodine; triphenylphosphine; In dichloromethane; at 20 ℃;

DOI:10.1016/j.bmcl.2006.10.080

Reference yield:

(3,5-dimethylphenyl)acetic acid (42288-46-0) → 1-(2-iodo-ethyl)-3,5-dimethyl-benzene (928775-73-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / Me₂S*BH₃ / tetrahydrofuran

2: I₂; PPh₃; imidazole / CH₂Cl₂ / 20 °C

With 1H-imidazole; dimethylsulfide borane complex; iodine; triphenylphosphine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.bmcl.2006.10.080

Reference yield:

1-(2-iodo-ethyl)-3,5-dimethyl-benzene (928775-73-9) → 4-[2-(3,5-dimethyl-phenyl)-ethyl]-6-(4-oxo-2-thioxo-thiazolidin-5-ylidenemethyl)-4H-benzo[1,4]oxazin-3-one

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃; benzyltriethylammonium chloride / acetonitrile / Heating

2: ethylenediamine diacetate / methanol / 20 °C

With N-benzyl-N,N,N-triethylammonium chloride; potassium carbonate; ethylenediamine diacetic acid; In methanol; acetonitrile;

DOI:10.1016/j.bmcl.2006.10.080

upstream raw materials:

β-(3,5-Dimethylphenyl)ethyl alcohol

(3,5-dimethylphenyl)acetic acid

Downstream raw materials:

4-[2-(3,5-dimethyl-phenyl)-ethyl]-3-oxo-3,4-dihydro-2H-benzo[1,4]oxazine-6-carbaldehyde

Refernces