Territrem A

Base Information

• Chemical Name: Territrem A
• CAS No.: 70407-19-1
• Molecular Formula: C28H30 O9
• Molecular Weight: 510.53
• DSSTox Substance ID: DTXSID40897214
• Wikidata: Q82873286
• Mol file: 70407-19-1.mol

Synonyms:territrem A

Chemical Property of Territrem A

Chemical Property:

• Vapor Pressure: 2.82E-20mmHg at 25°C
• Boiling Point: 695°C at 760 mmHg
• Flash Point: 232°C
• PSA: 124.66000
• Density: 1.44g/cm³
• LogP: 3.16510
• XLogP3: 2.7
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 2
• Exact Mass: 510.18898253
• Heavy Atom Count: 37
• Complexity: 1150

Purity/Quality:

98% ^*data from raw suppliers

Territrem A ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1(C=CC(=O)C2(C1(CCC3(C2(CC4=C(O3)C=C(OC4=O)C5=CC6=C(C(=C5)OC)OCO6)O)C)O)C)C
• Description: Territrem A is a mycotoxin originally isolated from A. terreus that irreversibly inhibits acetylcholinesterase (AChE; IC50 = 24 nM for the electric eel enzyme). It is toxic to mice, inducing tremors with a median tremulous dose of 0.31 mg/kg, and has an LD50 value of 17.6 mg/kg.
• Uses: Territrem A is an α-pyrone tremorgenic mycotoxin first identified from an Aspergillus terreus strain by Ling and colleagues at Taiwan National University in 1979. Territrem A is a potent insecticide acting via irreversible inhibition of acetylcholinesterase (AChE). The binding mechanism is very different from typical irreversible AChE inhibitors like neostigmine and the organophospates.