3,7,4'-TRIHYDROXYFLAVONE

Base Information

• Chemical Name: 3,7,4'-TRIHYDROXYFLAVONE
• CAS No.: 2034-65-3
• Molecular Formula: C15H10 O5
• Molecular Weight: 270.241
• Hs Code.: 2914501900
• Mol file: 2034-65-3.mol

Synonyms:Flavone,3,4',7-trihydroxy- (6CI,7CI,8CI); 3,4',7-Trihydroxyflavone;3,7,4'-Trihydroxyflavone; 4',7-Dihydroxyflavonol; 5-Deoxykaempferol;7,4'-Dihydroxyflavonol; Resokaempferol

Chemical Property of 3,7,4'-TRIHYDROXYFLAVONE

Chemical Property:

• Vapor Pressure: 1.76E-12mmHg at 25°C
• Melting Point: 310-311°C
• Boiling Point: 539.7°Cat760mmHg
• PKA: 6.85±0.40(Predicted)
• Flash Point: 210.6°C
• PSA: 90.90000
• Density: 1.579g/cm³
• LogP: 2.57680
• Storage Temp.: Hygroscopic, Refrigerator, under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

98%min ^*data from raw suppliers

3,7,4''-Trihydroxyflavone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,7,4'-TRIHYDROXYFLAVONE

There total 12 articles about 3,7,4'-TRIHYDROXYFLAVONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

3-hydroxy-7-methoxy-2-(4-methoxyphenyl)-4H-chromen-4-one (13198-99-7) → resokaempferol (2034-65-3)

Guidance literature:

With phosphorus pentachloride; In tetrahydrofuran; at 20 ℃; Inert atmosphere;

DOI:10.1002/ejic.200900769

Reference yield:

isoliquirtigenin (961-29-5,13745-20-5) → 4',6-dihydroxy-2-(α-hydroxybenzyl)coumaranone (14796-48-6) + 4-hydroxysalicylic acid (89-86-1) + resokaempferol (2034-65-3) + trans-3,4',7-trihydroxyflavanone (111915-65-2) + (2,4-dihydroxy-phenyl)-[4-(4-hydroxy-phenyl)-[1,2]dioxetan-3-yl]-methanone (61443-82-1) + chalaurenol (85359-61-1)

Guidance literature:

With air; methylene blue; In methanol; for 2h; Product distribution; Ambient temperature; Irradiation;

DOI:10.1016/S0031-9422(00)81859-2

Reference yield:

liquiritigenin (578-86-9,41680-09-5) → 3,7,4'-trihydroxyflavanone + resokaempferol (2034-65-3)

Guidance literature:

With isopropyl β-D-thiogalactopyranoside; at 30 ℃; Microbiological reaction;

upstream raw materials:

3,4'-dimethoxy-7-hydroxyflavone

isoliquirtigenin

2',4'-dihydroxy-2-methoxyacetophenone

p-Methoxybenzoic anhydride

Downstream raw materials:

3,7,3',4'-tetrahydroxyflavone

C₁₅H₁₀O₈S

Resokaempferol 3-glucuronide

C₂₁H₁₈O₁₁

Refernces

• 1、 Borsari, Chiara,Lucian, Rosaria,Pozzi, Cecilia,Poehner, Ina,Henrich, Stefan,Trande, Matteo,Cordeiro-Da-silva, Anabela,Santarem, Nuno,Baptista, Catarina,Tait, Annalisa,Di Pisa, Flavio,Iacono, Lucia Dello,Landi, Giacomo,Gul, Sheraz,Wolf, Markus,Kuzikov, Maria,Ellinger, Bernhard,Reinshagen, Jeanette,Witt, Gesa,Gribbon, Philip,Kohler, Manfred,Keminer, Oliver,Behrens, Birte,Costantino, Luca,Nevado, Paloma Tejera,Bifeld, Eugenia,Eick, Julia,Clos, Joachim,Torrado, Juan,Jiménez-Antón, María D.,Corral, María J.,Alunda, José Ma,Pellati, Federica,Wade, Rebecca C.,Ferrari, Stefania,Mangani, Stefano,Costi, Maria Paola. "Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs". . p. 7598 - 7616. Retrieved 2016/09/04.
• 2、 Wong, Edmon. "PHOTOOXYGENATION OF 2',4,4'-TRIHYDROXYCHALCONE: IDENTITY WITH PRODUCTS FROM ENZYMIC OXIDATION". . p. 1544 - 1545. Retrieved 2007/10/02.