1H-Pyrrole-3,4-dicarboxylic acid

Base Information

• Chemical Name: 1H-Pyrrole-3,4-dicarboxylic acid
• CAS No.: 935-72-8
• Molecular Formula: C6H5NO4
• Molecular Weight: 155.11
• Mol file: 935-72-8.mol

Synonyms:Pyrrole-3,4-dicarboxylic acid (6CI,7CI,8CI);NSC 625159;

Chemical Property of 1H-Pyrrole-3,4-dicarboxylic acid

Chemical Property:

• Melting Point: 311 - 313 °C
• Boiling Point: 480.705 °C at 760 mmHg
• PKA: 3.26±0.50(Predicted)
• Flash Point: 244.522 °C
• PSA: 90.39000
• Density: 1.671 g/cm³
• LogP: 0.41110

Purity/Quality:

99%, ^*data from raw suppliers

1H-pyrrole-3,4-dicarboxylicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Pyrrole-3,4-dicarboxylic acid

There total 7 articles about 1H-Pyrrole-3,4-dicarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

diethyl pyrrole-3,4-dicarboxylate (41969-71-5) → pyrrol-3,4-di-carboxylic acid (935-72-8)

Guidance literature:

With sodium hydroxide; In ethanol; water; for 2h; Heating;

DOI:10.1021/jo00171a053

Reference yield: 75.0%

L- trans-pyrrolidine-3,4-dicarboxylic acid (159694-26-5) → pyrrol-3,4-di-carboxylic acid (935-72-8)

Guidance literature:

With manganese(IV) oxide; silica gel; In dichloromethane; for 0.0833333h; Irradiation;

Reference yield:

diethyl (2E,3E)-2,3-bis[(dimethylamino)methylidene] succinate (39654-83-6) → pyrrol-3,4-di-carboxylic acid (935-72-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / ammonium acetate / aq. ethanol / 24 h / Heating

2: 95 percent / NaOH / ethanol; H₂O / 2 h / Heating

With ammonium acetate; sodium hydroxide; In ethanol; water;

DOI:10.1021/jo00171a053

upstream raw materials:

diethyl pyrrole-3,4-dicarboxylate

L- trans-pyrrolidine-3,4-dicarboxylic acid

diethyl (2E,3E)-2,3-bis[(dimethylamino)methylidene] succinate

diethyl 2-(diethoxymethyl)succinate

Downstream raw materials:

dimethyl pyrrole-3,4-dicarboxylate

3,4-Pyrroldicarbonylchlorid

pyrrole-3,4-dicarboxylic anhydride

4-(benzylcarbamoyl)pyrrole-3-carboxylic acid

Refernces

• 1、 Hale, Benjamin J.,Elshobaki, Moneim,Gebhardt, Ryan,Wheeler, David,Stoffer, Jon,Tomlinson, Aimée,Chaudhary, Sumit,Jeffries-EL, Malika. "Evaluating the influence of heteroatoms on the electronic properties of aryl[3,4-c]pyrroledione based copolymers". . p. 85 - 92. Retrieved 2016/12/26.
• 2、 Kaesler, Ralph W.,LeGoff, Eugene. "Synthesis of Porphyrinoctakis(dialkylcarboxamides)". . p. 4399 - 4402. Retrieved 2007/10/02.