4-Pyridinecarboxylic acid, 2-acetylphenyl ester

Base Information

• Chemical Name: 4-Pyridinecarboxylic acid, 2-acetylphenyl ester
• CAS No.: 93717-62-5
• Molecular Formula: C14H11NO3
• Molecular Weight: 241.246
• Mol file: 93717-62-5.mol

Synonyms:

Chemical Property of 4-Pyridinecarboxylic acid, 2-acetylphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-Pyridinecarboxylic acid, 2-acetylphenyl ester

There total 4 articles about 4-Pyridinecarboxylic acid, 2-acetylphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

isonicotinoyl chloride hydrochloride (39178-35-3) + o-hydroxyacetophenone (118-93-4,104809-67-8) → 2-acetylphenyl isonicotinate (93717-62-5)

Guidance literature:

With pyridine; at 20 ℃; for 15h;

Reference yield: 92.0%

4-(chlorocarbonyl)pyridine (14254-57-0) + o-hydroxyacetophenone (118-93-4,104809-67-8) → 2-acetylphenyl isonicotinate (93717-62-5)

Guidance literature:

With pyridine; at 20 ℃; for 3h;

DOI:10.1016/j.bmc.2008.01.021

Reference yield:

pyridine-4-carboxylic acid (55-22-1) → 2-acetylphenyl isonicotinate (93717-62-5)

Guidance literature:

Multi-step reaction with 2 steps

1: thionyl chloride / 12 h / Reflux

2: pyridine / dichloromethane / 3 h / 0 - 20 °C

With pyridine; thionyl chloride; In dichloromethane;

DOI:10.1021/acs.jmedchem.7b00523

upstream raw materials:

isonicotinoyl chloride hydrochloride

o-hydroxyacetophenone

4-(chlorocarbonyl)pyridine

pyridine-4-carboxylic acid

Downstream raw materials:

1-(2-hydroxyphenyl)-3-(pyridin-4-yl)propane-1,3-dione

2-((5-pyridin-4-yl)-1H-pyrazol-3-yl)phenol

3-(4-fluorophenyl)-2-(4-pyridyl)chromone

2-(4-pyridyl)-4H-chromone-4-one

Refernces

• 1、 Dyrager, Christine,M?llers, Linda Nilsson,Kj?ll, Linda Karlsson,Alao, John Patrick,Dinér, Peter,Wallner, Fredrik K.,Sunnerhagen, Per,Gr?til, Morten. "Design, synthesis, and biological evaluation of chromone-based p38 MAP kinase inhibitors". supporting information; experimental part. p. 7427 - 7431. Retrieved 2011/12/16.
• 2、 -. "PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF COMPLEX DISEASES AND THEIR DELIVERY BY INSERTABLE MEDICAL DEVICES". Page/Page column 60. . Retrieved 2008/06/13.