3-Chloro-2-methylanisole

Base Information

• Chemical Name: 3-Chloro-2-methylanisole
• CAS No.: 3260-88-6
• Molecular Formula: C8H9ClO
• Molecular Weight: 156.612
• Hs Code.: 2909309090
• European Community (EC) Number: 221-862-6
• UNII: B25BTP9CQM
• DSSTox Substance ID: DTXSID1074599
• Nikkaji Number: J262.360I
• Wikidata: Q82002868
• Mol file: 3260-88-6.mol

Synonyms:3-Chloro-2-methylanisole;3260-88-6;2-Methyl-3-chloroanisole;1-chloro-3-methoxy-2-methylbenzene;2-Chloro-6-methoxytoluene;BENZENE, 1-CHLORO-3-METHOXY-2-METHYL-;B25BTP9CQM;EINECS 221-862-6;MFCD00070772;2-METHOXY-6-CHLOROTOLUENE;POPSODISODIUMSALT;UNII-B25BTP9CQM;6-chloro-2-methoxytoluene;SCHEMBL844007;DTXSID1074599;LTVRGAWOEOKGJZ-UHFFFAOYSA-;AMY3937;3-Chloro-2-methylanisole, 90%;AKOS015849914;ANISOLE, 3-CHLORO-2-METHYL-;AC-25977;BS-16995;SY049178;CS-0153509;FT-0615352;A19911;C13337;J-509951;2-Methoxy-6-chlorotoluene;1-Chloro-3-methoxy-2-methylbenzene

Chemical Property of 3-Chloro-2-methylanisole

Chemical Property:

• Vapor Pressure: 0.427mmHg at 25°C
• Melting Point: -3 °C
• Refractive Index: n20/D 1.42(lit.)
• Boiling Point: 201.9 °C at 760 mmHg
• Flash Point: 82.1 °C
• PSA: 9.23000
• Density: 1.105 g/cm³
• LogP: 2.65700
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 156.0341926
• Heavy Atom Count: 10
• Complexity: 105

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-Chloro-6-methoxytoluene >96.0%(GC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: S24/25:Avoid contact with skin and eyes.

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1=C(C=CC=C1Cl)OC
• Uses: Arene-manganese tricarbonyl complexes are prepared using 3-Chloro-2-methylanisole.

Technology Process of 3-Chloro-2-methylanisole

There total 13 articles about 3-Chloro-2-methylanisole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.6%

methanol (67-56-1) + 2,6-dichlorotoluene (118-69-4) + sodium methylate (124-41-4) → 1-chloro-3-methoxy-2-methylbenzene (3260-88-6)

Guidance literature:

methanol; 2,6-dichlorotoluene; sodium methylate; In dimethyl sulfoxide; at 160 ℃; for 8h;

With polyethylene glycol 600; In dimethyl sulfoxide; at 80 ℃; for 2h; Temperature; Reagent/catalyst; Concentration;

Reference yield: 95.4%

→ 1-chloro-3-methoxy-2-methylbenzene (3260-88-6)

Guidance literature:

Reference yield:

2,6-dichlorotoluene (118-69-4) → 1-chloro-3-methoxy-2-methylbenzene (3260-88-6) + 3-chloro-o-cresol (3260-87-5)

Guidance literature:

With sodium methylate; dimethyl sulfoxide; In methanol;

upstream raw materials:

3-chloro-o-cresol

dimethyl sulfate

methanol

3-chloro-2-methylbenzenamine

Downstream raw materials:

3-methoxy-2-methylbenzonitrile

3-methoxy-2-methylbenzoic acid

2-chloro-6-methoxybenzaldehyde

methoxyfenoside

Refernces

• 1、 -. "2-methyl-3-methoxybenzoic acid and preparation method thereof". Paragraph 0034-0035; 0038-0039; 0042-0043; 0046-0047; 0050. . Retrieved 2020/05/01.
• 2、 -. "Synthesis method of 2-methyl-3-methoxybenzoic acid". Paragraph 0018. . Retrieved 2018/03/25.