MORPHOLIN-4-YL-PHENYL-ACETIC ACID

Base Information

• Chemical Name: MORPHOLIN-4-YL-PHENYL-ACETIC ACID
• CAS No.: 6342-19-4
• Molecular Formula: C12H15NO3
• Molecular Weight: 221.25
• Hs Code.: 2934999090
• Mol file: 6342-19-4.mol

Synonyms:NSC49409;alpha-Phenyl-4-morpholineacetic acid;

Chemical Property of MORPHOLIN-4-YL-PHENYL-ACETIC ACID

Chemical Property:

• Vapor Pressure: 1.96E-05mmHg at 25°C
• Melting Point: 202 °C (decomp)(Solv: benzene (71-43-2))
• Refractive Index: 1.574
• Boiling Point: 347.9 °C at 760 mmHg
• PKA: 1.76±0.10(Predicted)
• Flash Point: 164.2 °C
• PSA: 49.77000
• Density: 1.237 g/cm³
• LogP: 1.08240
• Storage Temp.: 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

Morpholin-4-yl-phenyl-acetic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38-36
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of MORPHOLIN-4-YL-PHENYL-ACETIC ACID

There total 5 articles about MORPHOLIN-4-YL-PHENYL-ACETIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ morpholin-4-yl(phenyl)acetic acid (6342-19-4)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01162a600

Reference yield:

α-morpholine methyl phenylacetate (100609-91-4) → morpholin-4-yl(phenyl)acetic acid (6342-19-4)

Guidance literature:

With sodium hydroxide; In methanol; water; for 8h; Heating;

DOI:10.1016/j.bmc.2006.02.028

Reference yield:

bromo-phenyl-acetic acid methyl ester (37167-62-7,3042-81-7,61139-20-6) → morpholin-4-yl(phenyl)acetic acid (6342-19-4)

Guidance literature:

Multi-step reaction with 2 steps

1: ethyldiisopropylamine / acetonitrile / 4 h / 20 °C

2: NaOH / methanol; H₂O / 8 h / Heating

With sodium hydroxide; N-ethyl-N,N-diisopropylamine; In methanol; water; acetonitrile;

DOI:10.1016/j.bmc.2006.02.028

upstream raw materials:

α-morpholine methyl phenylacetate

bromo-phenyl-acetic acid methyl ester

Downstream raw materials:

2-(morpholin-4-yl-phenyl-methyl)-1H-benzoimidazole

N-(2-aminophenyl)-2-morpholin-4-yl-2-phenylacetamide

Refernces