1-broMo-4-(ethoxyMethyl)benzene

Base Information

• Chemical Name: 1-broMo-4-(ethoxyMethyl)benzene
• CAS No.: 95068-22-7
• Molecular Formula: C9H11BrO
• Molecular Weight: 215.09
• Mol file: 95068-22-7.mol

Synonyms:1-bromo-4-(ethoxymethyl)benzene;1-Bromo-4-ethoxymethylbenzene;p-Bromobenzyl ethyl ether;

Chemical Property of 1-broMo-4-(ethoxyMethyl)benzene

Chemical Property:

• Boiling Point: 236.7±15.0 °C (760 mmHg)
• PSA: 9.23000
• Density: 1.333±0.06 g/cm3 (20 °C, 760 mmHg)
• LogP: 2.98560

Purity/Quality:

99% ^*data from raw suppliers

1-Bromo-4-(ethoxymethyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-broMo-4-(ethoxyMethyl)benzene

There total 7 articles about 1-broMo-4-(ethoxyMethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

ethanol (64-17-5) + 1-bromomethyl-4-bromobenzene (589-15-1) → 1-bromo-4-(ethoxymethyl)benzene (95068-22-7)

Guidance literature:

With silver(l) oxide; In hexane; dichloromethane; at 60 ℃; for 0.0833333h; Molecular sieve; Inert atmosphere; Sealed tube; Darkness;

DOI:10.1021/acs.joc.6b00144

Reference yield: 95.0%

diethoxymethylane (2031-62-1) + 4-bromo-benzaldehyde (1122-91-4) → 1-bromo-4-(ethoxymethyl)benzene (95068-22-7)

Guidance literature:

diethoxymethylane; 4-bromo-benzaldehyde; With dicarbonyl(pentamethylcyclopentadienyl)(4-methylphenyl)iron; In dichloromethane; for 4h; Inert atmosphere; Irradiation; Schlenk technique;

With sodium hydroxide; In methanol; water; Reagent/catalyst; Inert atmosphere; Schlenk technique;

DOI:10.1016/j.tetlet.2012.07.038

Reference yield: 48.0%

4-bromobenzenemethanol (873-75-6) + ethyl iodide (75-03-6) → 1-bromo-4-(ethoxymethyl)benzene (95068-22-7)

Guidance literature:

With sodium hydroxide; In N,N-dimethyl-formamide; at 20 ℃; for 2h;

upstream raw materials:

ethanol

1-bromomethyl-4-bromobenzene

Triethoxysilane

4-bromo-benzaldehyde

Downstream raw materials:

4-bromo-benzaldehyde

3-(6-(4-(ethoxymethyl)phenyl)thieno[3,2-d]pyrimidin-4-ylamino)phenol

2-(4-(ethoxymethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

4,4'-[sulfinylbis(methylene)]diphenol

Refernces

• 1、 Wang, Lei,Hashidoko, Yasuyuki,Hashimoto, Makoto. "Cosolvent-Promoted O-Benzylation with Silver(I) Oxide: Synthesis of 1′-Benzylated Sucrose Derivatives, Mechanistic Studies, and Scope Investigation". . p. 4464 - 4474. Retrieved 2016/07/06.
• 2、 Argouarch, Gilles,Grelaud, Guillaume,Roisnel, Thierry,Humphrey, Mark G.,Paul, Frédéric. "Reductive etherification of aldehydes photocatalyzed by dicarbonyl pentamethylcyclopentadienyl iron complexes". supporting information. p. 5015 - 5018. Retrieved 2012/11/07.