2-BROMO-N-ISOBUTYLACETAMIDE

Base Information

• Chemical Name: 2-BROMO-N-ISOBUTYLACETAMIDE
• CAS No.: 95331-76-3
• Molecular Formula: C6H12BrNO
• Molecular Weight: 194.071
• Hs Code.: 2924199090
• Mol file: 95331-76-3.mol

Synonyms:2-Bromo-N-isobutylacetamide;N-isobutyl 2-bromoacetamide;isobutyl bromoacetamide;bromo-acetic acid isobutylamide;N-isobutyl-2-bromoethanamide;

Chemical Property of 2-BROMO-N-ISOBUTYLACETAMIDE

Chemical Property:

• Vapor Pressure: 0.00537mmHg at 25°C
• Boiling Point: 274.5oC at 760 mmHg
• Flash Point: 119.8oC
• PSA: 29.10000
• Density: 1.319g/cm3
• LogP: 1.54440

Purity/Quality:

98%min ^*data from raw suppliers

2-bromo-N-isobutylacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-BROMO-N-ISOBUTYLACETAMIDE

There total 4 articles about 2-BROMO-N-ISOBUTYLACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-bromoacetyl chloride (22118-09-8) + isobutylamine (78-81-9) → 2-bromo-N-(2-methylpropyl)acetamide (95331-76-3)

Guidance literature:

In tetrahydrofuran; at -10 ℃;

DOI:10.1021/jo200289f

Reference yield: 80.0%

isobutylamine (78-81-9) + 2-Bromoacetyl bromide (598-21-0) → 2-bromo-N-(2-methylpropyl)acetamide (95331-76-3)

Guidance literature:

With potassium carbonate; In benzene; at 0 - 20 ℃;

DOI:10.1002/hlca.200590086

Reference yield:

isobutylamine (78-81-9) + bromoacetic acid (79-08-3) → 2-bromo-N-(2-methylpropyl)acetamide (95331-76-3)

Guidance literature:

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/jm070564e

upstream raw materials:

isobutylamine

2-Bromoacetyl bromide

bromoacetic acid

2-bromoacetyl chloride

Downstream raw materials:

(2E,4E)-N-isobutyl-5-phenylpenta-2,4-dienamide

(E)-N-isobutyl-3-(p-tolyl)acrylamide

4-Methoxy-N-isobutyl-zimtsaeureamid

N-isobutyl-(E)-cinnamamide

Refernces

• 1、 Matovic, Nicholas J.,Hayes, Patricia Y.,Penman, Kerry,Lehmann, Reginald P.,De Voss, James J.. "Polyunsaturated alkyl amides from echinacea: Synthesis of diynes, enynes, and dienes". scheme or table. p. 4467 - 4481. Retrieved 2011/07/30.
• 2、 Zhang, Shanrong,Jiang, Xiuyan,Sherry, A. Dean. "Modulation of the lifetime of water bound to lanthanide metal ions in complexes with ligands derived from 1,4,7,10-tetraazacyclododecane tetraacetate (DOTA)". . p. 923 - 935. Retrieved 2007/10/03.