N-(4-methoxyphenyl)-3-phenylpropanamide

Base Information

• Chemical Name: N-(4-methoxyphenyl)-3-phenylpropanamide
• CAS No.: 97754-31-9
• Molecular Formula: C16H17NO2
• Molecular Weight: 255.316
• Mol file: 97754-31-9.mol

Synonyms:p-Hydrocinnamanisidide;Hydrozimtsaeure-p-methoxyanilid;3-Phenyl-propionsaeure-<4-methoxy-anilid>;Propanamide,N-(3-methoxyphenyl)-3-phenyl;N-(4-methoxyphenyl)benzenepropanamide;Benzenepropanamide,N-(4-methoxyphenyl);F3147-1547;N-p-anisyl-3-phenylpropionamide;

Chemical Property of N-(4-methoxyphenyl)-3-phenylpropanamide

Chemical Property:

• PSA: 38.33000
• LogP: 3.33950

Purity/Quality:

99% ^*data from raw suppliers

N-(4-Methoxyphenyl)-3-phenylpropanamide 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(4-methoxyphenyl)-3-phenylpropanamide

There total 10 articles about N-(4-methoxyphenyl)-3-phenylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

N-(4-methoxyphenyl)-3-phenylacrylamide (76228-15-4,55044-94-5) → N-(4-methoxyphenyl)-3-phenylpropionamide (97754-31-9)

Guidance literature:

With borane-ammonia complex; In methanol; water; at 20 ℃; for 15h; Time; chemoselective reaction; Catalytic behavior;

DOI:10.1016/j.jorganchem.2021.122181

Reference yield: 96.0%

4-methoxyacetanilide (51-66-1) + benzyl alcohol (100-51-6,185532-71-2) → N-(4-methoxyphenyl)-3-phenylpropionamide (97754-31-9)

Guidance literature:

With tri-tert-butyl phosphine; potassium tert-butylate; nickel diacetate; In 1,4-dioxane; toluene; at 80 ℃; for 12h; Inert atmosphere; Glovebox; Schlenk technique;

DOI:10.1039/d0cc06468h

Reference yield: 95.0%

4-methoxy-aniline (104-94-9) + 3-Phenylpropionic acid (501-52-0) → N-(4-methoxyphenyl)-3-phenylpropionamide (97754-31-9)

Guidance literature:

3-Phenylpropionic acid; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; at 20 ℃; for 0.166667h;

4-methoxy-aniline; at 20 ℃; for 1h;

DOI:10.1039/c8ob00653a

upstream raw materials:

4-methoxy-aniline

hydrocinnamic acid chloride

4-methoxyacetanilide

benzyl alcohol

Downstream raw materials:

N-(4-methoxyphenyl)-3-phenylpropylamine

4-phenylazetidin-2-one

1-(4-methoxy-phenyl)-4-phenyl-azetidin-2-one

1-(4-methoxyphenyl)-3,4-dihydroquinolin-2(1H)-one

Refernces

• 1、 Mishiro, Kenji,Nomura, Mitsuki,Furuyama, Taniyuki,Kunishima, Munetaka. "Efficiency Enhancement of a Photocatalytic Decarbonylation of an Aminocyclopropenone by Benzothiophene Substitution". . p. 3625 - 3636. Retrieved 2021/03/03.
• 2、 Yang, Peng,Wang, Xiuhua,Ma, Yu,Sun, Yaxin,Zhang, Li,Yue, Jieyu,Fu, Kaiyue,Zhou, Jianrong Steve,Tang, Bo. "Nickel-catalyzed: C-alkylation of thioamide, amides and esters by primary alcohols through a hydrogen autotransfer strategy". supporting information. p. 14083 - 14086. Retrieved 2020/11/20.