N-[4-(difluoromethoxy)-2-nitrophenyl]acetamide

Base Information

• Chemical Name: N-[4-(difluoromethoxy)-2-nitrophenyl]acetamide
• CAS No.: 97963-75-2
• Molecular Formula: C9H8F2N2O4
• Molecular Weight: 246.17
• Mol file: 97963-75-2.mol

Synonyms:

Chemical Property of N-[4-(difluoromethoxy)-2-nitrophenyl]acetamide

Chemical Property:

• Melting Point: 69 - 70°C
• Boiling Point: 425.3±45.0 °C(Predicted)
• PKA: 13.01±0.70(Predicted)
• PSA: 87.64000
• Density: 1.451±0.06 g/cm3(Predicted)
• LogP: 3.32730
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

N-(4-DIFLUOROMETHOXY-2-NITRO-PHENYL)-ACETAMIDE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: N-(4-Difluoromethoxy-2-nitrophenyl)acetamide is a key reagent used in the preparation of 2-mercapto-5-difluoromethoxy-1H-benzimidazole; an important medicinal intermediate.

Technology Process of N-[4-(difluoromethoxy)-2-nitrophenyl]acetamide

There total 3 articles about N-[4-(difluoromethoxy)-2-nitrophenyl]acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

N-[4-(difluoromethoxy)phenyl]-acetamide (22236-11-9) → N-[(4-difluoromethoxy-2-nitro)phenyl]-acetamide (97963-75-2)

Guidance literature:

With nitric acid; acetic anhydride; In chloroform; for 0.5h; Heating / reflux;

Reference yield:

4-acetaminophenol (103-90-2,8055-08-1) → N-[(4-difluoromethoxy-2-nitro)phenyl]-acetamide (97963-75-2)

Guidance literature:

Multi-step reaction with 2 steps

1: PEG-600 / 50 - 55 °C

2: nitric acid; sulfuric acid / 2 h / 20 - 25 °C

With sulfuric acid; nitric acid;

DOI:10.14233/ajchem.2013.14818

Reference yield:

→ N-[(4-difluoromethoxy-2-nitro)phenyl]-acetamide (97963-75-2)

Guidance literature:

upstream raw materials:

N-[4-(difluoromethoxy)phenyl]-acetamide

4-acetaminophenol

Downstream raw materials:

4-difluoromethoxy-2-nitroaniline

SKA-47

4-(difluoromethoxy)benzene-1,2-diamine

Refernces

• 1、 -. "Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof". Page/Page column 64-65. . Retrieved 2010/11/26.
• 2、 -. "INDOLES, 1H-INDAZOLES, 1,2-BENZISOXAZOLES, AND 1,2-BENZISOTHIAZOLES, AND PREPARATION AND USES THEREOF". Page/Page column 48. . Retrieved 2008/06/13.