2-(2-Bromo-5-methoxyphenyl)-1,3-dioxolane

Base Information

• Chemical Name: 2-(2-Bromo-5-methoxyphenyl)-1,3-dioxolane
• CAS No.: 98015-07-7
• Molecular Formula: C10H11BrO3
• Molecular Weight: 259.1
• DSSTox Substance ID: DTXSID90458051
• Nikkaji Number: J1.577.041D
• Wikidata: Q82281179
• Mol file: 98015-07-7.mol

Synonyms:2-(2-bromo-5-methoxyphenyl)-1,3-dioxolane;98015-07-7;1,3-Dioxolane, 2-(2-bromo-5-methoxyphenyl)-;2-(2-bromo-5-methoxyphenyl)-[1,3]dioxolane;SCHEMBL1119892;DTXSID90458051;DKBDCPFMXOLYID-UHFFFAOYSA-N;MFCD06209830;AM87508;CS-0193421;E89940

Chemical Property of 2-(2-Bromo-5-methoxyphenyl)-1,3-dioxolane

Chemical Property:

• PSA: 27.69000
• LogP: 2.50310
• XLogP3: 2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 257.98916
• Heavy Atom Count: 14
• Complexity: 182

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Bromo-5-methoxyphenyl)-1,3-dioxolane 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC(=C(C=C1)Br)C2OCCO2

Technology Process of 2-(2-Bromo-5-methoxyphenyl)-1,3-dioxolane

There total 10 articles about 2-(2-Bromo-5-methoxyphenyl)-1,3-dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-bromo-5-methoxy-benzaldehyde (7507-86-0) + ethylene glycol (107-21-1) → 2-Bromo-5-methoxybenzaldehyde ethylene glycol acetal (98015-07-7)

Guidance literature:

With toluene-4-sulfonic acid; In toluene; for 12h; Heating;

DOI:10.1021/jo00221a030

Reference yield: 70.0%

ethylene glycol (107-21-1) + 3-methoxy-benzaldehyde (591-31-1) → 2-Bromo-5-methoxybenzaldehyde ethylene glycol acetal (98015-07-7)

Guidance literature:

3-methoxy-benzaldehyde; With bromine; In chloroform; Heating;

ethylene glycol; With toluene-4-sulfonic acid; In benzene; at 100 ℃;

DOI:10.1021/jo049722p

Reference yield:

2-bromo-5-methoxy-benzaldehyde (7507-86-0) → 2-Bromo-5-methoxybenzaldehyde ethylene glycol acetal (98015-07-7)

Guidance literature:

With p-toluenesulfonic acid monohydrate; In ethylene glycol; benzene;

upstream raw materials:

2-bromo-5-methoxy-benzaldehyde

ethylene glycol

3-methoxy-benzaldehyde

5-methoxy-2-nitro-benzaldehyde

Downstream raw materials:

2-<2-(1,3-dioxalanyl)>-4-methoxybenzaldehyde

benzyl ether of (E)-dehydromarchantin I

4-{2-[3-(2-[1,3]Dioxolan-2-yl-4-methoxy-phenoxy)-phenyl]-ethyl}-2-(4-hydroxymethyl-phenoxy)-phenol

Refernces

• 1、 Ma, Shuang-Shuang,Jiang, Biao-Ling,Yu, Zheng-Kun,Zhang, Suo-Jiang,Xu, Bao-Hua. "Cobalt-Catalyzed Chemoselective Transfer Hydrogenative Cyclization Cascade of Enone-Tethered Aldehydes". supporting information. p. 3873 - 3878. Retrieved 2021/05/26.
• 2、 Xi, Junwei,Gu, Zhenhua. "Palladium-Catalzyed Atroposelective 16-Membered Macrocyclization: Total Synthesis of Isoplagiochin D?". supporting information. p. 1081 - 1085. Retrieved 2020/07/06.