Isowighteone

Base Information

• Chemical Name: Isowighteone
• CAS No.: 68436-47-5
• Molecular Formula: C20H18O5
• Molecular Weight: 338.36
• UNII: P89WCN5Q95
• DSSTox Substance ID: DTXSID801317874
• Nikkaji Number: J45.334J
• Wikidata: Q27138091
• Metabolomics Workbench ID: 22329
• ChEMBL ID: CHEMBL464460
• Mol file: 68436-47-5.mol

Synonyms:isowighteone;68436-47-5;3'-Prenylgenistein;5,7,4'-Trihydroxy-3'-prenylisoflavone;3'-(gamma,gamma-dimethylallyl)genistein;5,7-dihydroxy-3-[4-hydroxy-3-(3-methylbut-2-enyl)phenyl]chromen-4-one;CHEBI:69749;5,7-Dihydroxy-3-(4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl)-4H-chromen-4-one;CHEMBL1812593;3'-prenyl-5,7,4'-trihydroxyisoflavone;5,7-dihydroxy-3-[4-hydroxy-3-(3-methylbut-2-en-1-yl)phenyl]-4H-chromen-4-one;3'-isoprenylgenistein;CHEMBL464460;3'-(g,g-Dimethylallyl)genistein;DTXSID801317874;HY-N3448;BDBM50349975;LMPK12050192;AKOS032962333;CS-0024260;Q27138091;5,7-Dihydroxy-3-[4-hydroxy-3-(3-methyl-2-butenyl)phenyl]-4H-1-benzopyran-4-one, 9CI;5,7-Dihydroxy-3-[4-hydroxy-3-(3-methyl-but-2-enyl)-phenyl]-chromen-4-one

Chemical Property of Isowighteone

Chemical Property:

• PSA: 90.90000
• LogP: 4.08550
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 3
• Exact Mass: 338.11542367
• Heavy Atom Count: 25
• Complexity: 562

Purity/Quality:

98%min ^*data from raw suppliers

Isowighteone ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=CCC1=C(C=CC(=C1)C2=COC3=CC(=CC(=C3C2=O)O)O)O)C
• Uses: Isowighteone is a natural product derivative of Genistein (G350000). Genistein exhibits specific inhibitory activity against tyrosine kinases, including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol.

Technology Process of Isowighteone

There total 1 articles about Isowighteone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 3'-isoprenylgenistein (68436-47-5)

Guidance literature:

DOI:10.1246/bcsj.51.2398