1-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE

Base Information

• Chemical Name: 1-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE
• CAS No.: 73930-39-9
• Molecular Formula: C9H12ClN
• Molecular Weight: 169.654
• Hs Code.: 2921499090
• Mol file: 73930-39-9.mol

Synonyms:Cyclopropanamine,1-phenyl-, hydrochloride (9CI);Cyclopropylamine, 1-phenyl-, hydrochloride(7CI);(1-Phenylcyclopropyl)amine hydrochloride;1-phenylcyclopropanamine hydrochloride (1:1);1-Phenylcyclopropanaminhydrochlorid(1:1);Cyclopropanamine, 1-phenyl-, hydrochloride (1:1);1-Phenylcyclopropanamine hydrochloride (1:1);

Chemical Property of 1-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE

Chemical Property:

• Vapor Pressure: 0.183mmHg at 25°C
• Melting Point: 194.7-194.9 °C
• Boiling Point: 211.4 °C at 760 mmHg
• Flash Point: 85.5 °C
• PSA: 26.02000
• LogP: 3.13670
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

1-PhenylcyclopropanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE

There total 8 articles about 1-PHENYL-CYCLOPROPYLAMINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

1-phenylcyclopropylamine tert-butyl carbamate → 1-phenylcyclopropane-1-amine hydrochloride (73930-39-9,95216-83-4)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 0 - 20 ℃; for 24h;

DOI:10.1002/cmdc.201900730

Reference yield: 71.0%

1-phenyl-1-cyclopropane carboxylic acid (6120-95-2) → 1-phenylcyclopropane-1-amine hydrochloride (73930-39-9,95216-83-4)

Guidance literature:

With sodium azide; sulfuric acid; In chloroform;

Reference yield: 51.0%

hydrogenchloride (7647-01-0,15364-23-5) + 1-phenyl-1-cyclopropane carboxylic acid (6120-95-2) → 1-phenylcyclopropane-1-amine hydrochloride (73930-39-9,95216-83-4)

Guidance literature:

1-phenyl-1-cyclopropane carboxylic acid; With diphenyl phosphoryl azide; triethylamine; In toluene; for 0.75h; Reflux;

hydrogenchloride; In diethyl ether; for 0.5h; Heating;

DOI:10.1021/acsmedchemlett.7b00094

upstream raw materials:

1-phenylcyclopropanecarbonyl chloride

1-phenyl-1-cyclopropane carboxylic acid

benzonitrile

1-phenylcyclopropylamine

Downstream raw materials:

ethyl 2-((1-phenylcyclopropyl)amino)pyrimidine-5-carboxylate

N-hydroxy-2-((1-phenylcyclopropyl)amino)pyrimidine-5-carboxamide

N(1-phenylcyclopropyl)-benzamide

Refernces

• 1、 Ermolovich, Yuri,Barysevich, Maryia V.,Adamson, Jasper,Rogova, Oksana,Kaabel, Sandra,J?rving, Ivar,Gathergood, Nicholas,Snieckus, Victor,Kananovich, Dzmitry G.. "Site-Selective and Stereoselective C-H Functionalization of N-Cyclopropylamides via a Directed Remote Metalation Strategy". supporting information. p. 969 - 973. Retrieved 2019/02/14.
• 2、 -. "INCREASING EXPRESSION OF INTERFERON REGULATED GENES WITH COMBINATONS OF HISTONE DEACETYLASE INHIBITORS AND IMMUNOMODULATORY DRUGS". Page/Page column 53; 54. . Retrieved 2017/09/08.