2-Amino-5-iodobenzaldehyde

Base Information

• Chemical Name: 2-Amino-5-iodobenzaldehyde
• CAS No.: 99471-71-3
• Molecular Formula: C7H6INO
• Molecular Weight: 247.035
• Mol file: 99471-71-3.mol

Synonyms:

Chemical Property of 2-Amino-5-iodobenzaldehyde

Chemical Property:

• PSA: 43.09000
• LogP: 2.26710

Purity/Quality:

98% ^*data from raw suppliers

2-Amino-5-iodobenzaldehyde 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Amino-5-iodobenzaldehyde

There total 4 articles about 2-Amino-5-iodobenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

(2-amino-5-iodophenyl)methanol (53279-83-7) → 2-amino-5-iodobenzaldehyde (99471-71-3)

Guidance literature:

With manganese(IV) oxide; In dichloromethane; for 6h; Ambient temperature;

DOI:10.1021/jm00118a034

Reference yield:

methyl 2-amino-5-iodobenzoate (77317-55-6) → 2-amino-5-iodobenzaldehyde (99471-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / diiisobutylaluminium hydride / tetrahydrofuran / 16 h / Ambient temperature

2: 81 percent / MnO₂ / CH₂Cl₂ / 6 h / Ambient temperature

With manganese(IV) oxide; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00118a034

Reference yield:

o-aminobenzaldehyde (529-23-7) → 2-amino-5-iodobenzaldehyde (99471-71-3)

Guidance literature:

With N-iodo-succinimide; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

upstream raw materials:

(2-amino-5-iodophenyl)methanol

methyl 2-amino-5-iodobenzoate

2-amino-5-iodobenzoic acid

o-aminobenzaldehyde

Downstream raw materials:

6-iodo-2-methylquinoline

3,5-dibromo-2-amino benzaldehyde

Refernces

• 1、 -. "HARMFUL ARTHROPOD CONTROL METHOD USING HETEROCYCLIC COMPOUND". Paragraph 0372. . Retrieved 2021/02/02.
• 2、 Reddy, C. B. Rajashekar,Reddy, Sabbasani Rajasekhara,Naidu, Shivaji. "Chemoselective Oxidation of Benzyl, Amino, and Propargyl Alcohols to Aldehydes and Ketones under Mild Reaction Conditions". . p. 107 - 110. Retrieved 2015/04/27.