Technology Process of 1-Piperidinecarboxylic acid, 4-formyl-, ethyl ester
There total 3 articles about 1-Piperidinecarboxylic acid, 4-formyl-, ethyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
ethyl 4-(hydroxymethyl)-1-piperidinecarboxylate;
With
oxalyl dichloride; dimethyl sulfoxide;
In
dichloromethane;
at -78 ℃;
for 0.75h;
With
triethylamine;
In
dichloromethane;
at -78 - 20 ℃;
for 1h;
With
sodium hydrogencarbonate;
In
dichloromethane; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: triethylamine / dichloromethane / 0.42 h / 0 - 20 °C
2.1: oxalyl dichloride; dimethyl sulfoxide / dichloromethane / 0.5 h / -78 °C
2.2: 1 h / 20 °C
With
oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane;
2.1: Swern Oxidation;
