Benzene, 1,5-bis(1,1-dimethylethyl)-2-methoxy-3-nitro-

Base Information

• Chemical Name: Benzene, 1,5-bis(1,1-dimethylethyl)-2-methoxy-3-nitro-
• CAS No.: 99758-42-6
• Molecular Formula: C15H23NO3
• Molecular Weight: 265.353
• Mol file: 99758-42-6.mol

Synonyms:2,4-di-tert-butyl-6-nitro-anisole;

Chemical Property of Benzene, 1,5-bis(1,1-dimethylethyl)-2-methoxy-3-nitro-

Chemical Property:

• PSA: 55.05000
• LogP: 4.72160

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzene, 1,5-bis(1,1-dimethylethyl)-2-methoxy-3-nitro-

There total 3 articles about Benzene, 1,5-bis(1,1-dimethylethyl)-2-methoxy-3-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,4-di-tert-butyl-6-nitrophenol (20039-94-5) + methyl iodide (74-88-4) → 1,5-di-tert-butyl-2-methoxy-3-nitrobenzene (99758-42-6)

Guidance literature:

With potassium carbonate; In acetone; at 70 ℃; for 20h;

DOI:10.1021/acs.inorgchem.9b00784

Reference yield: 81.0%

2,4-di-tert-butylmethoxybenzene (17177-98-9) → 1,5-di-tert-butyl-2-methoxy-3-nitrobenzene (99758-42-6)

Guidance literature:

With tetrabutylammonium nitrate; trifluoroacetic anhydride; In dichloromethane; at 0 - 20 ℃; for 2h;

Reference yield:

2,4-di-tert-Butylphenol (96-76-4) → 1,5-di-tert-butyl-2-methoxy-3-nitrobenzene (99758-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1: nitric acid; acetic acid / 2 h / Cooling with ice

2: potassium carbonate / acetone / 20 h / 70 °C

With nitric acid; potassium carbonate; acetic acid; In acetone;

DOI:10.1021/acs.inorgchem.9b00784

upstream raw materials:

2,4-di-tert-butylmethoxybenzene

2,4-di-tert-Butylphenol

2,4-di-tert-butyl-6-nitrophenol

methyl iodide

Downstream raw materials:

3,5-di-tert-butyl-2-methoxyaniline

2-tert-butyl-4,6-dinitro-anisole

Refernces

• 1、 -. "PHENOL-HETEROCYCLIC LIGANDS, METAL COMPLEXES, AND THEIR USES AS CATALYSTS". Page/Page column 81-82. . Retrieved 2010/11/08.