N2-Methylpyridine-2,3-diamine

Base Information

• Chemical Name: N2-Methylpyridine-2,3-diamine
• CAS No.: 5028-20-6
• Molecular Formula: C6H9N3
• Molecular Weight: 123.158
• Hs Code.: 2933399090
• European Community (EC) Number: 818-909-3
• ChEMBL ID: CHEMBL4533256
• DSSTox Substance ID: DTXSID40492465
• Nikkaji Number: J1.567.729E
• Wikidata: Q72496614
• Mol file: 5028-20-6.mol

Synonyms:N2-Methylpyridine-2,3-diamine;5028-20-6;N2-Methyl-2,3-pyridinediamine;n2-methyl-pyridine-2,3-diamine;2-N-methylpyridine-2,3-diamine;3-amino-2-methylaminopyridine;2,3-Pyridinediamine, N2-methyl-;N~2~-methylpyridine-2,3-diamine;3-Amino-2-methylaminopyridin;2-methylamino-3-aminopyridine;N-Methylpyridine-2,3-diamine;SCHEMBL2947216;CHEMBL4533256;DTXSID40492465;COANMWJRJDRXNS-UHFFFAOYSA-N;3-amino-2-(N-methylamino)-pyridine;MFCD08692132;AKOS005202681;SB75490;AC-25098;DS-15642;BB 0257209;CS-0046883;FT-0681483;EN300-58631;AB01005618-01;A852941;F2113-0168

Chemical Property of N2-Methylpyridine-2,3-diamine

Chemical Property:

• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 100-101 °C
• Refractive Index: 1.652
• Boiling Point: 303.553 °C at 760 mmHg
• PKA: 7.04±0.10(Predicted)
• Flash Point: 137.384 °C
• PSA: 50.94000
• Density: 1.18 g/cm³
• LogP: 1.35970
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• XLogP3: 0.5
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 123.079647300
• Heavy Atom Count: 9
• Complexity: 84.4

Purity/Quality:

98%,99%, ^*data from raw suppliers

N2-Methylpyridine-2,3-diamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=C(C=CC=N1)N
• Uses: N2-Methylpyridine-2,3-diamine is a useful reagent in synthesis of imidazopyridines, which show tuberculostatic activity.

Technology Process of N2-Methylpyridine-2,3-diamine

There total 13 articles about N2-Methylpyridine-2,3-diamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

2-(methylamino)-3-nitropyridine (4093-88-3) → 3-amino-2-methylaminopyridine (5028-20-6)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 6h; under 2625.26 Torr;

DOI:10.1002/chem.201703908

Reference yield: 99.0%

→ 3-amino-2-methylaminopyridine (5028-20-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 4h; under 760.051 Torr;

Reference yield: 91.0%

(3-Amino-pyridin-2-yl)-carbamic acid methyl ester (99315-00-1) → 3-amino-2-methylaminopyridine (5028-20-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; for 0.5h; Heating;

DOI:10.1002/jhet.5570220216

upstream raw materials:

2-chloro-3-aminopyridine

methylamine

2-(methylamino)-3-nitropyridine

(3-Amino-pyridin-2-yl)-carbamic acid methyl ester

Downstream raw materials:

3-(3-Methyl-3H-2-imidazo<4,5-b>pyridine)propionic acid

4-methyl-1,4-dihydropyrido[2,3-b]piperazine-2,3-dione

3-methyl-2-N-(p-toluenesulfonyl)aminoimidazo[4,5-b]pyridine

N₂-methyl-N₃-phenylpyridine-2,3-diamine

Refernces

• 1、 Dong, Yaxi,Breit, Bernhard. "Cu-Catalyzed C-H Allylation of Benzimidazoles with Allenes". supporting information. p. 6765 - 6769. Retrieved 2021/09/11.
• 2、 Chouha, Nora,Hammoud, Hassan,Brogi, Simone,Campiani, Giuseppe,Welsch, Caroline,Robert, Caroline,Vagner, Stéphan,Cresteil, Thierry,Bentouhami, Embarek,Désaubry, Laurent. "Discovery of iminobenzimidazole derivatives as novel cytotoxic agents". . p. 74 - 83. Retrieved 2018/09/29.