4-Prop-2-yn-1-ylmorpholine

Base Information

• Chemical Name: 4-Prop-2-yn-1-ylmorpholine
• CAS No.: 149965-78-6
• Molecular Formula: C7H11NO
• Molecular Weight: 203.241
• Hs Code.: 2924299090
• Mol file: 149965-78-6.mol

Synonyms:Morpholine, 4-(2-propyn-1-yl)-;

Chemical Property of 4-Prop-2-yn-1-ylmorpholine

Chemical Property:

• Boiling Point: 168.1 °C at 760 mmHg
• PKA: 11.90±0.46(Predicted)
• Flash Point: 45.8 °C
• PSA: 12.47000
• Density: 0.99 g/cm³
• LogP: -0.11030
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

BenzylBut-3-Yn-1-ylcarbamate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-Prop-2-yn-1-ylmorpholine

There total 4 articles about 4-Prop-2-yn-1-ylmorpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

4-amino-1-butyne hydrochloride (88211-50-1) + benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonyl-but-3-ynyl-1-amine (149965-78-6)

Guidance literature:

4-amino-1-butyne hydrochloride; With potassium carbonate; In dichloromethane; at 0 - 25 ℃; for 2.5h;

benzyl chloroformate; at 25 ℃; for 14h;

DOI:10.1021/acs.jmedchem.0c01249

Reference yield: 71.5%

but-3-yn-1-amine hydrochloride + benzyl chloroformate (501-53-1,94274-21-2) → N-benzyloxycarbonyl-but-3-ynyl-1-amine (149965-78-6)

Guidance literature:

With sodium hydrogencarbonate; In ethanol; water; at 0 - 25 ℃;

DOI:10.1016/j.ejmech.2019.03.037

Reference yield:

phthalimide (136918-14-4,85-41-6) → N-benzyloxycarbonyl-but-3-ynyl-1-amine (149965-78-6)

Guidance literature:

With hydrogenchloride; hydrazine hydrate; In ethanol;

upstream raw materials:

phthalimide

4-pentynoic acid

benzyl alcohol

benzyl chloroformate

Downstream raw materials:

(4-Bromo-but-3-ynyl)-carbamic acid benzyl ester

[4-(4-Iodophenyl)but-3-ynyl]carbamic acid benzyl ester

benzyl but-3-ynyl(methoxymethyl)carbamate

C₃₁H₃₄N₂O₆

Refernces

• 1、 Li, Xue-Meng,Lv, Wei,Guo, Si-Yang,Li, Ya-Xin,Fan, Bing-Zhi,Cushman, Mark,Kong, Fan-Sheng,Zhang, Jun,Liang, Jian-Hua. "Synthesis and structure-bactericidal activity relationships of non-ketolides: 9-Oxime clarithromycin 11,12-cyclic carbonate featured with three-to eight-atom-length spacers at 3-OH". supporting information. p. 235 - 254. Retrieved 2019/03/27.
• 2、 -. "Prodrugs activated by targeted catalytic proteins". . . Retrieved 2008/06/13.