benzofuran-4-yl trifluoromethanesulfonate

Base Information

• Chemical Name: benzofuran-4-yl trifluoromethanesulfonate
• CAS No.: 177734-79-1
• Molecular Formula: C9H5F3O4S
• Molecular Weight: 266.198
• Mol file: 177734-79-1.mol

Synonyms:benzofuran-4-yl trifluoromethanesulfonate;4-(Trifluoromethylsulfonyloxy)benzofuran;Trifluoromethanesulfonic acid benzofuran-4-yl ester;1-benzofuran-4-yl trifluoroMethanesulfonate

Chemical Property of benzofuran-4-yl trifluoromethanesulfonate

Chemical Property:

• PSA: 64.89000
• Density: 1.586
• LogP: 3.74200

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of benzofuran-4-yl trifluoromethanesulfonate

There total 4 articles about benzofuran-4-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

4-hydroxybenzofuran (480-97-7) + trifluoroacetic anhydride (407-25-0) → benzofuran-4-yl trifluoromethanesulfonate (177734-79-1)

Guidance literature:

With pyridine; dmap; In dichloromethane; at 0 ℃; for 2h;

DOI:10.1016/j.bmc.2018.02.026

Reference yield:

4-hydroxybenzofuran (480-97-7) + trifluoromethylsulfonic anhydride (358-23-6) → benzofuran-4-yl trifluoromethanesulfonate (177734-79-1)

Guidance literature:

With 2,6-dimethylpyridine; In dichloromethane; at -78 - 0 ℃; for 1h; Inert atmosphere;

Reference yield:

3-carboxy-4-hydroxybenzo-(b)-furan (112678-09-8) → benzofuran-4-yl trifluoromethanesulfonate (177734-79-1)

Guidance literature:

Multi-step reaction with 2 steps

1: copper / quinoline / 5 h / 230 °C

2: 2,6-dimethylpyridine / dichloromethane / 1 h / -78 - 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; copper; In quinoline; dichloromethane;

upstream raw materials:

4-hydroxybenzofuran

trifluoromethylsulfonic anhydride

3-carboxy-4-hydroxybenzo-(b)-furan

trifluoroacetic anhydride

Downstream raw materials:

4-acetylbenzofuran

benzofuran-4-carboxylic acid

Refernces

• 1、 -. "NOVEL TRICYCLIC CALCIUM SENSING RECEPTOR ANTAGONISTS". Page/Page column 47. . Retrieved 2015/07/07.
• 2、 -. "Anti-cancer agents and uses thereof". Page/Page column 49. . Retrieved 2008/12/08.