(R)-2-Azetidinemethanol

Base Information

• Chemical Name: (R)-2-Azetidinemethanol
• CAS No.: 209329-11-3
• Molecular Formula: C4H9NO
• Molecular Weight: 87.1204
• Hs Code.: 2933998090
• Mol file: 209329-11-3.mol

Synonyms:(R)-2-AZETIDINEMETHANOL;(R)-Azetidin-2-yl-methanol;(R)-Azetidine-2-Methanol

Chemical Property of (R)-2-Azetidinemethanol

Chemical Property:

• Boiling Point: 151.879 °C at 760 mmHg
• PKA: 14.77±0.10(Predicted)
• Flash Point: 84.291 °C
• PSA: 32.26000
• Density: 1.018g/cm³
• LogP: -0.33060
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

99% ^*data from raw suppliers

(R)-2-Azetidinemethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (R)-2-Azetidinemethanol is used in the preparation of various compounds that are neprilysin inhibitors, which are useful in the treatment of hypertension, heart failure and renal disease alone or in combination therapy.

Technology Process of (R)-2-Azetidinemethanol

There total 1 articles about (R)-2-Azetidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

benzyl (2R)-4-oxoazetidine-2-carboxylate (95729-87-6) → (2R)-2-azetidinylmethanol (209329-11-3,250274-91-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran;

DOI:10.1016/S0957-4166(98)00291-2

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + (2R)-2-azetidinylmethanol (209329-11-3,250274-91-0) → (R)-1-t-butyloxycarbonyl-2-azetidinemethanol (161511-90-6)

Guidance literature:

In tetrahydrofuran; Yield given;

DOI:10.1016/S0957-4166(98)00291-2

Reference yield:

2-(4'-fluorophenyl)-tricyclo[3.3.1.13,7]decane-2-acetic acid (400081-87-0) + (2R)-2-azetidinylmethanol (209329-11-3,250274-91-0) → C22H28FNO2

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine;

DOI:10.1021/acs.jmedchem.7b00211

upstream raw materials:

benzyl (2R)-4-oxoazetidine-2-carboxylate

Downstream raw materials:

(R)-1-t-butyloxycarbonyl-2-azetidinemethanol

Refernces