(1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide

Base Information

• Chemical Name: (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide
• CAS No.: 1006376-62-0
• Molecular Formula: C10H9F2NO
• Molecular Weight: 197.184
• Hs Code.: 2924297099
• Mol file: 1006376-62-0.mol

Synonyms:(1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide

Chemical Property of (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide

Chemical Property:

• Boiling Point: 347.9±42.0 °C(Predicted)
• PKA: 16.43±0.40(Predicted)
• PSA: 44.08000
• Density: 1.366±0.06 g/cm3(Predicted)
• LogP: 2.70330
• Storage Temp.: 2-8°C
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99.9% ^*data from raw suppliers

(1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (1R,2R)-2-(3,4-Difluorophenyl)cyclopropanecarboxamide is a part of the synthetic preparation of the synthesis and inhibitory effect on ADP-induced platelet aggregation of ticagrelor derivatives as antiplatelets agents.

Technology Process of (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide

There total 30 articles about (1R,2R)-2-(3,4-difluorophenyl)cyclopropane carboxaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

(1R,2R)-2-(3,4-difluorophenyl)cyclopropane carbonitrile (1450916-28-5) → (1R,2R)-trans-2(3,4-difluorophenyl)cyclopropyl carboxamide (1006376-62-0)

Guidance literature:

With dihydrogen peroxide; potassium carbonate; In water; dimethyl sulfoxide; at 20 ℃; for 3h; Solvent; Temperature;

Reference yield: 91.0%

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanoic acid methyl ester (1459720-02-5) → (1R,2R)-trans-2(3,4-difluorophenyl)cyclopropyl carboxamide (1006376-62-0)

Guidance literature:

With ammonium hydroxide; In methanol; at 50 - 55 ℃;

Reference yield: 91.0%

C13H14F2O2 → (1R,2R)-trans-2(3,4-difluorophenyl)cyclopropyl carboxamide (1006376-62-0)

Guidance literature:

With ammonium hydroxide; In methanol; at 50 - 55 ℃;

upstream raw materials:

trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarbonyl chloride

(1R,2R)-2-(3,4-difluorophenyl)-1-cyclopropanecarboxylic acid ethyl ester

trans-(1R,2R)-2-(3,4-difluorophenyl)cyclopropanecarboxylic acid

(1S)-2-chloro-1-(3,4-difluorophenyl)-1-ethanol

Downstream raw materials:

(1R,2S)-2-(3,4-difluorophenyl)cyclopropanamine

ticagrelor

AR-C₁₂₄₉₁₀XX

(3aR,4S,6R,6aS)-6-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydro-3aH-cyclopenta[d][1,3]dioxol-4-ol

Refernces

• 1、 -. "Preparation method of chiral aromatic cyclopropylamine and salt thereof and intermediate used in preparation method". . . Retrieved 2020/06/20.
• 2、 -. "Preparation method of ticagrelor". . . Retrieved 2018/04/21.